TY - JOUR
T1 - Epidemiology and burden of systemic lupus erythematosus in a Southern European population
T2 - data from the community-based lupus registry of Crete, Greece
AU - Gergianaki, Irini
AU - Fanouriakis, Antonis
AU - Repa, Argyro
AU - Tzanakakis, Michalis
AU - Adamichou, Christina
AU - Pompieri, Alexandra
AU - Spirou, Giorgis
AU - Bertsias, Antonios
AU - Kabouraki, Eleni
AU - Tzanakis, Ioannis
AU - Chatzi, Leda
AU - Sidiropoulos, Prodromos
AU - Boumpas, Dimitrios T.
AU - Bertsias, George K.
PY - 2017/12
Y1 - 2017/12
N2 - Objectives Several population-based studies on systemic lupus erythematosus (SLE) have been reported, yet community-based, individual-case validated, comprehensive reports are missing. We studied the SLE epidemiology and burden on the island of Crete during 1999-2013.Methods Multisource case-finding included patients >= 15 years old. Cases were ascertained by the ACR 1997, SLICC 2012 criteria and rheumatologist diagnosis, and validated through synthesis of medical charts, administrative and patient-generated data.Results Overall age-adjusted/sex-adjusted incidence was 7.4 (95% CI 6.8 to 7.9) per 100 000 persons/year, with stabilising trends in women but increasing in men, and average (+/- SD) age of diagnosis at 43 (+/- 15) years. Adjusted and crude prevalence (December 2013) was 123.4 (113.9 to 132.9) and 143 (133 to 154)/10(5) (165/10(5) in urban vs 123/10(5) in rural regions, pConclusions By the use of a comprehensive methodology, we describe the full spectrum of SLE from the community to tertiary care, with almost half of the cases having mild disease, yet with significant damage accrual. SLE is not rare, affects predominantly middle-aged women and is increasingly recognised in men. Neuropsychiatric disease is an emerging frontier in lupus prevention and care.
AB - Objectives Several population-based studies on systemic lupus erythematosus (SLE) have been reported, yet community-based, individual-case validated, comprehensive reports are missing. We studied the SLE epidemiology and burden on the island of Crete during 1999-2013.Methods Multisource case-finding included patients >= 15 years old. Cases were ascertained by the ACR 1997, SLICC 2012 criteria and rheumatologist diagnosis, and validated through synthesis of medical charts, administrative and patient-generated data.Results Overall age-adjusted/sex-adjusted incidence was 7.4 (95% CI 6.8 to 7.9) per 100 000 persons/year, with stabilising trends in women but increasing in men, and average (+/- SD) age of diagnosis at 43 (+/- 15) years. Adjusted and crude prevalence (December 2013) was 123.4 (113.9 to 132.9) and 143 (133 to 154)/10(5) (165/10(5) in urban vs 123/10(5) in rural regions, pConclusions By the use of a comprehensive methodology, we describe the full spectrum of SLE from the community to tertiary care, with almost half of the cases having mild disease, yet with significant damage accrual. SLE is not rare, affects predominantly middle-aged women and is increasingly recognised in men. Neuropsychiatric disease is an emerging frontier in lupus prevention and care.
KW - COLLEGE-OF-RHEUMATOLOGY
KW - CLINICS CLASSIFICATION CRITERIA
KW - DISEASE-ACTIVITY INDEX
KW - STAGE RENAL-DISEASE
KW - NORTHWEST GREECE
KW - UPDATED VERSION
KW - DAMAGE INDEX
KW - BILAG 2004
KW - PREVALENCE
KW - NEPHRITIS
U2 - 10.1136/annrheumdis-2017-211206
DO - 10.1136/annrheumdis-2017-211206
M3 - Article
C2 - 28780511
SN - 0003-4967
VL - 76
SP - 1992
EP - 2000
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
IS - 12
ER -