Epidemiology and burden of systemic lupus erythematosus in a Southern European population: data from the community-based lupus registry of Crete, Greece

Irini Gergianaki, Antonis Fanouriakis, Argyro Repa, Michalis Tzanakakis, Christina Adamichou, Alexandra Pompieri, Giorgis Spirou, Antonios Bertsias, Eleni Kabouraki, Ioannis Tzanakis, Leda Chatzi, Prodromos Sidiropoulos, Dimitrios T. Boumpas*, George K. Bertsias

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Objectives Several population-based studies on systemic lupus erythematosus (SLE) have been reported, yet community-based, individual-case validated, comprehensive reports are missing. We studied the SLE epidemiology and burden on the island of Crete during 1999-2013.

Methods Multisource case-finding included patients >= 15 years old. Cases were ascertained by the ACR 1997, SLICC 2012 criteria and rheumatologist diagnosis, and validated through synthesis of medical charts, administrative and patient-generated data.

Results Overall age-adjusted/sex-adjusted incidence was 7.4 (95% CI 6.8 to 7.9) per 100 000 persons/year, with stabilising trends in women but increasing in men, and average (+/- SD) age of diagnosis at 43 (+/- 15) years. Adjusted and crude prevalence (December 2013) was 123.4 (113.9 to 132.9) and 143 (133 to 154)/10(5) (165/10(5) in urban vs 123/10(5) in rural regions, p

Conclusions By the use of a comprehensive methodology, we describe the full spectrum of SLE from the community to tertiary care, with almost half of the cases having mild disease, yet with significant damage accrual. SLE is not rare, affects predominantly middle-aged women and is increasingly recognised in men. Neuropsychiatric disease is an emerging frontier in lupus prevention and care.

Original languageEnglish
Pages (from-to)1992-2000
Number of pages9
JournalAnnals of the Rheumatic Diseases
Volume76
Issue number12
DOIs
Publication statusPublished - Dec 2017

Keywords

  • COLLEGE-OF-RHEUMATOLOGY
  • CLINICS CLASSIFICATION CRITERIA
  • DISEASE-ACTIVITY INDEX
  • STAGE RENAL-DISEASE
  • NORTHWEST GREECE
  • UPDATED VERSION
  • DAMAGE INDEX
  • BILAG 2004
  • PREVALENCE
  • NEPHRITIS

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