Abstract
Recent work has shown that the transition from persistent to permanent AF in goats coincides with an increase in fibrosis in the outer millimeter of the atrial wall. Macroscopically this leads to reduced electrical conductivity orthogonal to the dominant fiber orientation.We constructed a detailed geometry of the human atria including epicardial layer and all major endocardial bundle structures. The model also includes realistic one to three layers of fiber orientations, corresponding to their location in the atrium.The numbers of waves, phase singularities, and breakthroughs (BTs) were quantified at different degrees of fibrotic tissue. Increase in the "fibrotic" volume from zero (Control) to moderate (50% Fibrotic), and severe (70% Fibrotic) increased both the number of waves and the number of phase singularities. Along with the increase in fibrosis, the endo-epicardial electrical activity dyssynchrony increased.
Original language | English |
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Title of host publication | 2016 COMPUTING IN CARDIOLOGY CONFERENCE (CINC), VOL 43 |
Publisher | IEEE |
Pages | 237-240 |
Number of pages | 4 |
Volume | 43 |
ISBN (Print) | 9781509008957 |
Publication status | Published - 2016 |
Event | 43rd Computing in Cardiology Conference (CinC) - Vancouver, Canada Duration: 11 Sept 2016 → 14 Sept 2016 http://www.cinc2016.org/ |
Publication series
Series | Computing in Cardiology Conference |
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Volume | 43 |
ISSN | 2325-8861 |
Conference
Conference | 43rd Computing in Cardiology Conference (CinC) |
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Abbreviated title | CinC 2016 |
Country/Territory | Canada |
City | Vancouver |
Period | 11/09/16 → 14/09/16 |
Internet address |
Keywords
- PERSISTENT
- MECHANISMS