Enhancing regenerative approaches with nanoparticles

Sabine van Rijt*, Pamela Habibovic

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

In this review, we discuss recent developments in the field of nanoparticles and their use in tissue regeneration approaches. Owing to their unique chemical properties and flexibility in design, nanoparticles can be used as drug delivery systems, to create novel features within materials or as bioimaging agents, or indeed these properties can be combined to create smart multifunctional structures. This review aims to provide an overview of this research field where the focus will be on nanoparticle-based strategies to stimulate bone regeneration; however, the same principles can be applied for other tissue and organ regeneration strategies. In the first section, nanoparticlebased methods for the delivery of drugs, growth factors and genetic material to promote tissue regeneration are discussed. The second section deals with the addition of nanoparticles to materials to create nanocomposites. Such materials can improve several material properties, including mechanical stability, biocompatibility and biological activity. The third section will deal with the emergence of a relatively new field of research using nanoparticles in advanced cell imaging and stem cell tracking approaches. As the development of nanoparticles continues, incorporation of this technology in the field of regenerative medicine will ultimately lead to new tools that can diagnose, track and stimulate the growth of new tissues and organs.

Original languageEnglish
Article number20170093
Number of pages10
JournalJournal of the Royal Society Interface
Volume14
Issue number129
DOIs
Publication statusPublished - 1 Apr 2017

Keywords

  • nanoparticles
  • regenerative medicine
  • tissue engineering
  • bone regeneration
  • drug delivery
  • stem cell tracking
  • MESENCHYMAL STEM-CELLS
  • TISSUE ENGINEERING APPLICATIONS
  • DRUG-DELIVERY SYSTEMS
  • BONE REGENERATION
  • CALCIUM-PHOSPHATE
  • CONTROLLED-RELEASE
  • GROWTH-FACTORS
  • QUANTUM DOTS
  • IN-VITRO
  • SILICA NANOPARTICLES

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