Enhanced vitamin K expenditure as a major contributor to vitamin K deficiency in COVID-19

Margot P J Visser; Jona Walk; Cees Vermeer; Simona Bílková; Rob Janssen; Otto Mayer

doi:10.1016/j.ijid.2022.10.030

Enhanced vitamin K expenditure as a major contributor to vitamin K deficiency in COVID-19

Margot P J Visser^*, Jona Walk, Cees Vermeer, Simona Bílková, Rob Janssen, Otto Mayer

^*Corresponding author for this work

Carim - Vascular aspects thrombosis and Haemostasis

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVES: Vitamin K deficiency consistently associates with worse clinical outcome in COVID-19 patients. However, whether this is due to increased expenditure during inflammation or poor vitamin K status prior to infection remained unknown.

METHODS: Dp-ucMGP levels of 128 individuals were measured for the post-MONICA study and were compared to SARS-CoV-2 PCR testing results.

RESULTS: Dp-ucMGP levels prior to COVID-19 infection were not significantly different comparing PCR-negative, PCR-positive and not hospitalized, and PCR-positive and hospitalized patients.

CONCLUSION: In this study, we demonstrate normal vitamin K status prior to infection in SARS-CoV-2 positive patients, supporting the theory of increased utilisation during disease.

Original language	English
Pages (from-to)	275-277
Number of pages	3
Journal	International Journal of Infectious Diseases
Volume	125
DOIs	https://doi.org/10.1016/j.ijid.2022.10.030
Publication status	Published - Dec 2022

Keywords

Humans
Vitamin K
Health Expenditures
Extracellular Matrix Proteins
Calcium-Binding Proteins
COVID-19
SARS-CoV-2
Vitamin K Deficiency/complications
Biomarkers

Access to Document

10.1016/j.ijid.2022.10.030Licence: CC BY

Cite this

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title = "Enhanced vitamin K expenditure as a major contributor to vitamin K deficiency in COVID-19",

abstract = "OBJECTIVES: Vitamin K deficiency consistently associates with worse clinical outcome in COVID-19 patients. However, whether this is due to increased expenditure during inflammation or poor vitamin K status prior to infection remained unknown.METHODS: Dp-ucMGP levels of 128 individuals were measured for the post-MONICA study and were compared to SARS-CoV-2 PCR testing results.RESULTS: Dp-ucMGP levels prior to COVID-19 infection were not significantly different comparing PCR-negative, PCR-positive and not hospitalized, and PCR-positive and hospitalized patients.CONCLUSION: In this study, we demonstrate normal vitamin K status prior to infection in SARS-CoV-2 positive patients, supporting the theory of increased utilisation during disease.",

keywords = "Humans, Vitamin K, Health Expenditures, Extracellular Matrix Proteins, Calcium-Binding Proteins, COVID-19, SARS-CoV-2, Vitamin K Deficiency/complications, Biomarkers",

author = "Visser, {Margot P J} and Jona Walk and Cees Vermeer and Simona B{\'i}lkov{\'a} and Rob Janssen and Otto Mayer",

year = "2022",

month = dec,

doi = "10.1016/j.ijid.2022.10.030",

language = "English",

volume = "125",

pages = "275--277",

journal = "International Journal of Infectious Diseases",

issn = "1201-9712",

publisher = "ELSEVIER SCI LTD",

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TY - JOUR

T1 - Enhanced vitamin K expenditure as a major contributor to vitamin K deficiency in COVID-19

AU - Visser, Margot P J

AU - Walk, Jona

AU - Vermeer, Cees

AU - Bílková, Simona

AU - Janssen, Rob

AU - Mayer, Otto

PY - 2022/12

Y1 - 2022/12

N2 - OBJECTIVES: Vitamin K deficiency consistently associates with worse clinical outcome in COVID-19 patients. However, whether this is due to increased expenditure during inflammation or poor vitamin K status prior to infection remained unknown.METHODS: Dp-ucMGP levels of 128 individuals were measured for the post-MONICA study and were compared to SARS-CoV-2 PCR testing results.RESULTS: Dp-ucMGP levels prior to COVID-19 infection were not significantly different comparing PCR-negative, PCR-positive and not hospitalized, and PCR-positive and hospitalized patients.CONCLUSION: In this study, we demonstrate normal vitamin K status prior to infection in SARS-CoV-2 positive patients, supporting the theory of increased utilisation during disease.

AB - OBJECTIVES: Vitamin K deficiency consistently associates with worse clinical outcome in COVID-19 patients. However, whether this is due to increased expenditure during inflammation or poor vitamin K status prior to infection remained unknown.METHODS: Dp-ucMGP levels of 128 individuals were measured for the post-MONICA study and were compared to SARS-CoV-2 PCR testing results.RESULTS: Dp-ucMGP levels prior to COVID-19 infection were not significantly different comparing PCR-negative, PCR-positive and not hospitalized, and PCR-positive and hospitalized patients.CONCLUSION: In this study, we demonstrate normal vitamin K status prior to infection in SARS-CoV-2 positive patients, supporting the theory of increased utilisation during disease.

KW - Humans

KW - Vitamin K

KW - Health Expenditures

KW - Extracellular Matrix Proteins

KW - Calcium-Binding Proteins

KW - COVID-19

KW - SARS-CoV-2

KW - Vitamin K Deficiency/complications

KW - Biomarkers

U2 - 10.1016/j.ijid.2022.10.030

DO - 10.1016/j.ijid.2022.10.030

M3 - Article

C2 - 36511328

SN - 1201-9712

VL - 125

SP - 275

EP - 277

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

ER -