Engineering molecularly imprinted polymers (MIPs) for the selective extraction and quantification of the novel psychoactive substance (NPS) methoxphenidine and its regioisomers

J. W. Lowdon; S. M. O. Alkirkit; R. E. Mewis; D. Fulton; C. E. Banks; O. B. Sutcliffe; M. Peeters

doi:10.1039/c8an00131f

Engineering molecularly imprinted polymers (MIPs) for the selective extraction and quantification of the novel psychoactive substance (NPS) methoxphenidine and its regioisomers

J. W. Lowdon, S. M. O. Alkirkit, R. E. Mewis, D. Fulton, C. E. Banks, O. B. Sutcliffe^*, M. Peeters^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In this communication, we present the first developed Molecularly Imprinted Polymers (MIPs) for the specific detection of a New Psychoactive Substance (NPS); namely, methoxphenidine (MXP) and its regioisomers. Selectivity of the MIP towards MXP is studied by analysing mixtures and an acquired street sample with High Performance Liquid Chromatography coupled to UV detection. The study demonstrates that the engineered polymers selectively extract MXP from heterogeneous samples, which makes for a very powerful diagnostic tool that can detect traces of MXP in complicated NPS samples.

Original language	English
Pages (from-to)	2002-2007
Number of pages	6
Journal	Analyst
Volume	143
Issue number	9
DOIs	https://doi.org/10.1039/c8an00131f
Publication status	Published - 7 May 2018

Keywords

SOLID-PHASE EXTRACTION
DIPHENIDINE

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10.1039/c8an00131fLicence: CC BY-NC

Cite this

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title = "Engineering molecularly imprinted polymers (MIPs) for the selective extraction and quantification of the novel psychoactive substance (NPS) methoxphenidine and its regioisomers",

abstract = "In this communication, we present the first developed Molecularly Imprinted Polymers (MIPs) for the specific detection of a New Psychoactive Substance (NPS); namely, methoxphenidine (MXP) and its regioisomers. Selectivity of the MIP towards MXP is studied by analysing mixtures and an acquired street sample with High Performance Liquid Chromatography coupled to UV detection. The study demonstrates that the engineered polymers selectively extract MXP from heterogeneous samples, which makes for a very powerful diagnostic tool that can detect traces of MXP in complicated NPS samples.",

keywords = "SOLID-PHASE EXTRACTION, DIPHENIDINE",

author = "Lowdon, {J. W.} and Alkirkit, {S. M. O.} and Mewis, {R. E.} and D. Fulton and Banks, {C. E.} and Sutcliffe, {O. B.} and M. Peeters",

year = "2018",

month = may,

day = "7",

doi = "10.1039/c8an00131f",

language = "English",

volume = "143",

pages = "2002--2007",

journal = "Analyst",

issn = "0003-2654",

publisher = "Royal Society of Chemistry",

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Engineering molecularly imprinted polymers (MIPs) for the selective extraction and quantification of the novel psychoactive substance (NPS) methoxphenidine and its regioisomers. / Lowdon, J. W.; Alkirkit, S. M. O.; Mewis, R. E. et al.
In: Analyst, Vol. 143, No. 9, 07.05.2018, p. 2002-2007.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Engineering molecularly imprinted polymers (MIPs) for the selective extraction and quantification of the novel psychoactive substance (NPS) methoxphenidine and its regioisomers

AU - Lowdon, J. W.

AU - Alkirkit, S. M. O.

AU - Mewis, R. E.

AU - Fulton, D.

AU - Banks, C. E.

AU - Sutcliffe, O. B.

AU - Peeters, M.

PY - 2018/5/7

Y1 - 2018/5/7

N2 - In this communication, we present the first developed Molecularly Imprinted Polymers (MIPs) for the specific detection of a New Psychoactive Substance (NPS); namely, methoxphenidine (MXP) and its regioisomers. Selectivity of the MIP towards MXP is studied by analysing mixtures and an acquired street sample with High Performance Liquid Chromatography coupled to UV detection. The study demonstrates that the engineered polymers selectively extract MXP from heterogeneous samples, which makes for a very powerful diagnostic tool that can detect traces of MXP in complicated NPS samples.

AB - In this communication, we present the first developed Molecularly Imprinted Polymers (MIPs) for the specific detection of a New Psychoactive Substance (NPS); namely, methoxphenidine (MXP) and its regioisomers. Selectivity of the MIP towards MXP is studied by analysing mixtures and an acquired street sample with High Performance Liquid Chromatography coupled to UV detection. The study demonstrates that the engineered polymers selectively extract MXP from heterogeneous samples, which makes for a very powerful diagnostic tool that can detect traces of MXP in complicated NPS samples.

KW - SOLID-PHASE EXTRACTION

KW - DIPHENIDINE

U2 - 10.1039/c8an00131f

DO - 10.1039/c8an00131f

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SN - 0003-2654

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SP - 2002

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