Engineered Micro-Objects as Scaffolding Elements in Cellular Building Blocks for Bottom-Up Tissue Engineering Approaches

A. Leferink, D. Schipper, E. Arts, E. Vrij, N. Rivron, M. Karperien, K. Mittmann, C. van Blitterswijk, L. Moroni, R. Truckenmueller

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Abstract

A material-based bottom-up approach is proposed towards an assembly of cells and engineered micro-objects at the macroscale. We show how shape, size and wettability of engineered micro-objects play an important role in the behavior of cells on these objects. This approach can, among other applications, be used as a tool to engineer complex 3D tissues of clinically relevant size.
Original languageEnglish
Pages (from-to)2592-2599
JournalAdvanced Materials
Volume26
Issue number16
DOIs
Publication statusPublished - Apr 2014

Keywords

  • bottom-up tissue engineering
  • micro-objects
  • human mesenchymal stromal cells
  • cell aggregates
  • biofabrication

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