Engaging Diverse Social and Cultural Worlds: Perspectives on Benefits in International Clinical Research From South African Communities

O. Zvonareva, N. Engel, E. Ross, R. Berghmans, A. Dhai, A. Krumeich

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

The issue of benefits in international clinical research is highly controversial. Against the background of wide recognition of the need to share benefits of research, the nature of benefits remains strongly contested. Little is known about the perspectives of research populations on this issue and the extent to which research ethics discourses and guidelines are salient to the expectations and aspirations existing on the ground. This exploratory study contributes to filling this void by examining perspectives of people in low-income South African communities on benefits in international clinical research. Twenty-four individuals with and without experience of being involved in clinical research participated in in-depth interviews. Respondents felt that ancillary care should be provided to clinical research participants, while a clinical study conducted in particular community should bring better health to its members through post-trial benefits. Respondents' perspectives were grounded in the perception that the ultimate goal of international clinical research is to improve local health. We argue that perspectives and understandings of the respondents are shaped by local moral traditions rather than clinical research specificities and require attention as valid moral claims. It is necessary to acknowledge such claims and cultural worlds from which they emerge, thus building the foundation for equal and embracing dialogue to bridge different perspectives and handle contradicting expectations.

Original languageEnglish
Pages (from-to)8-17
Number of pages10
JournalDeveloping World Bioethics
Volume15
Issue number1
Early online date31 May 2013
DOIs
Publication statusPublished - Apr 2015

Keywords

  • benefit sharing
  • bioethics
  • South Africa
  • clinical trials
  • culture
  • local perspectives
  • HIV PREVENTION TRIALS
  • MEDICAL-RESEARCH
  • RESEARCH ETHICS
  • VACCINE TRIAL
  • PARTICIPANTS
  • BIOETHICS
  • SCIENCE
  • VIEWS

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