Endothelium-associated biomarkers mid-regional proadrenomedullin and C-terminal proendothelin-1 have good ability to predict 28-day mortality in critically ill patients with SARS-CoV-2 pneumonia: A prospective cohort study

J.A.H. van Oers*, Y. Kluiters, J.A.P. Bons, M. de Jongh, S. Pouwels, D. Ramnarain, D.W. de Lange, H.J. de Grooth, A.R.J. Girbes

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Purpose: We assessed the ability of mid-regional proadrenomedullin (MR-proADM) and C-terminal proendothelin-1 (CT-proET-1) to predict 28-day mortality in critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. Methods: Biomarkers were collected during the first seven days in this prospective observational cohort study. We investigated the relationship between biomarkers and mortality in a multivariable Cox regression model adjusted for age and SOFA score. Results: In 105 critically ill patients with confirmed SARS-CoV-2 pneumonia 28-day mortality was 28.6%. MRproADM and CT-proET-1 were significantly higher in 28-day non-survivors at baseline and over time. ROC curves revealed high accuracy to identify non-survivors for baseline MR-proADM and CT-proET-1, AUC 0.84, (95% CI 0.76-0.92), p < 0.001 and 0.79, (95% CI 0.69-0.89), p < 0.001, respectively. The AUC for prediction of 28-day mortality for MR-proADM and CT-proET-1 remained high over time. MR-proADM >_1.57 nmol/L and CT-proET-1 >_ 111 pmol/L at baseline were significant predictors for 28-day mortality (HR 6.80, 95% CI 3.12-14.84, p < 0.001 and HR 3.72, 95% CI 1.71-8.08, p 0.01). Conclusion: Baseline and serial MR-proADM and CT-proET-1 had good ability to predict 28-day mortality in critically ill patients with SARS-CoV-2 pneumonia. Trial registration: NEDERLANDS TRIAL REGISTER, NL8460. (c) 2021 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)173-180
Number of pages8
JournalJournal of Critical Care
Volume66
DOIs
Publication statusPublished - 1 Dec 2021

Keywords

  • MR-proADM
  • CT-proET-1
  • COVID-19
  • Critically ill
  • PRECURSOR FRAGMENT
  • COVID-19 PATIENTS
  • ADRENOMEDULLIN
  • SURVIVAL
  • PLASMA

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