Endothelial function in patients with chronic obstructive pulmonary disease: a systematic review of studies using flow mediated dilatation

Anouk W. Vaes; Martijn A. Spruit; Jan Theunis; Nandu Goswami; Lowie E. Vanfleteren; Frits M. E. Franssen; Emiel F. M. Wouters; Patrick De Boever

doi:10.1080/17476348.2017.1389277

Endothelial function in patients with chronic obstructive pulmonary disease: a systematic review of studies using flow mediated dilatation

Anouk W. Vaes^*, Martijn A. Spruit, Jan Theunis, Nandu Goswami, Lowie E. Vanfleteren, Frits M. E. Franssen, Emiel F. M. Wouters, Patrick De Boever

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Background: Cardiovascular disease is an important cause of morbidity and mortality in chronic obstructive pulmonary disease (COPD). Endothelial function may be involved in the pathogenesis of cardiovascular disease. In contrast to the attention given to pulmonary endothelial dysfunction, little is known about peripheral vascular changes in COPD. Therefore, we reviewed the literature on peripheral endothelial function in COPD.Methods: Databases were screened for studies using ultrasound-based flow-mediated dilation (FMD), the reference method for assessing peripheral endothelial function, in stable COPD patients. Pooled effect sizes were calculated using random effects model.Results: 17 studies were identified, with a total of 1228 participants (724 COPD patients; 504 controls). Pooled analysis demonstrated an impaired endothelial-dependent FMD (-3.22%; 95% confidence interval (CI) -4.74 to -1.69; p

Original language	English
Pages (from-to)	1021-1031
Number of pages	11
Journal	Expert Review of Respiratory Medicine
Volume	11
Issue number	12
DOIs	https://doi.org/10.1080/17476348.2017.1389277
Publication status	Published - 2017

Keywords

COPD
cardiovascular disease
endothelial function
flow mediated dilatation
cardiovascular risk
RANDOMIZED CONTROLLED-TRIAL
CORONARY-ARTERY-DISEASE
VASCULAR DYSFUNCTION
CARDIOVASCULAR RISK
BLOOD-FLOW
CLINICAL-PRACTICE
LUNG-FUNCTION
EX-SMOKERS
DILATION

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10.1080/17476348.2017.1389277

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Vaes, A. W., Spruit, M. A., Theunis, J., Goswami, N., Vanfleteren, L. E., Franssen, F. M. E., Wouters, E. F. M., & De Boever, P. (2017). Endothelial function in patients with chronic obstructive pulmonary disease: a systematic review of studies using flow mediated dilatation. Expert Review of Respiratory Medicine, 11(12), 1021-1031. https://doi.org/10.1080/17476348.2017.1389277

@article{d1a002d9b327459cb910926965408626,

title = "Endothelial function in patients with chronic obstructive pulmonary disease: a systematic review of studies using flow mediated dilatation",

abstract = "Background: Cardiovascular disease is an important cause of morbidity and mortality in chronic obstructive pulmonary disease (COPD). Endothelial function may be involved in the pathogenesis of cardiovascular disease. In contrast to the attention given to pulmonary endothelial dysfunction, little is known about peripheral vascular changes in COPD. Therefore, we reviewed the literature on peripheral endothelial function in COPD.Methods: Databases were screened for studies using ultrasound-based flow-mediated dilation (FMD), the reference method for assessing peripheral endothelial function, in stable COPD patients. Pooled effect sizes were calculated using random effects model.Results: 17 studies were identified, with a total of 1228 participants (724 COPD patients; 504 controls). Pooled analysis demonstrated an impaired endothelial-dependent FMD (-3.22%; 95% confidence interval (CI) -4.74 to -1.69; p",

keywords = "COPD, cardiovascular disease, endothelial function, flow mediated dilatation, cardiovascular risk, RANDOMIZED CONTROLLED-TRIAL, CORONARY-ARTERY-DISEASE, VASCULAR DYSFUNCTION, CARDIOVASCULAR RISK, BLOOD-FLOW, CLINICAL-PRACTICE, LUNG-FUNCTION, EX-SMOKERS, DILATION",

author = "Vaes, {Anouk W.} and Spruit, {Martijn A.} and Jan Theunis and Nandu Goswami and Vanfleteren, {Lowie E.} and Franssen, {Frits M. E.} and Wouters, {Emiel F. M.} and {De Boever}, Patrick",

year = "2017",

doi = "10.1080/17476348.2017.1389277",

language = "English",

volume = "11",

pages = "1021--1031",

journal = "Expert Review of Respiratory Medicine",

issn = "1747-6348",

publisher = "Routledge/Taylor & Francis Group",

number = "12",

}

Vaes, AW, Spruit, MA, Theunis, J, Goswami, N, Vanfleteren, LE, Franssen, FME , Wouters, EFM & De Boever, P 2017, 'Endothelial function in patients with chronic obstructive pulmonary disease: a systematic review of studies using flow mediated dilatation', Expert Review of Respiratory Medicine, vol. 11, no. 12, pp. 1021-1031. https://doi.org/10.1080/17476348.2017.1389277

TY - JOUR

T1 - Endothelial function in patients with chronic obstructive pulmonary disease

T2 - a systematic review of studies using flow mediated dilatation

AU - Vaes, Anouk W.

AU - Spruit, Martijn A.

AU - Theunis, Jan

AU - Goswami, Nandu

AU - Vanfleteren, Lowie E.

AU - Franssen, Frits M. E.

AU - Wouters, Emiel F. M.

AU - De Boever, Patrick

PY - 2017

Y1 - 2017

N2 - Background: Cardiovascular disease is an important cause of morbidity and mortality in chronic obstructive pulmonary disease (COPD). Endothelial function may be involved in the pathogenesis of cardiovascular disease. In contrast to the attention given to pulmonary endothelial dysfunction, little is known about peripheral vascular changes in COPD. Therefore, we reviewed the literature on peripheral endothelial function in COPD.Methods: Databases were screened for studies using ultrasound-based flow-mediated dilation (FMD), the reference method for assessing peripheral endothelial function, in stable COPD patients. Pooled effect sizes were calculated using random effects model.Results: 17 studies were identified, with a total of 1228 participants (724 COPD patients; 504 controls). Pooled analysis demonstrated an impaired endothelial-dependent FMD (-3.22%; 95% confidence interval (CI) -4.74 to -1.69; p

AB - Background: Cardiovascular disease is an important cause of morbidity and mortality in chronic obstructive pulmonary disease (COPD). Endothelial function may be involved in the pathogenesis of cardiovascular disease. In contrast to the attention given to pulmonary endothelial dysfunction, little is known about peripheral vascular changes in COPD. Therefore, we reviewed the literature on peripheral endothelial function in COPD.Methods: Databases were screened for studies using ultrasound-based flow-mediated dilation (FMD), the reference method for assessing peripheral endothelial function, in stable COPD patients. Pooled effect sizes were calculated using random effects model.Results: 17 studies were identified, with a total of 1228 participants (724 COPD patients; 504 controls). Pooled analysis demonstrated an impaired endothelial-dependent FMD (-3.22%; 95% confidence interval (CI) -4.74 to -1.69; p

KW - COPD

KW - cardiovascular disease

KW - endothelial function

KW - flow mediated dilatation

KW - cardiovascular risk

KW - RANDOMIZED CONTROLLED-TRIAL

KW - CORONARY-ARTERY-DISEASE

KW - VASCULAR DYSFUNCTION

KW - CARDIOVASCULAR RISK

KW - BLOOD-FLOW

KW - CLINICAL-PRACTICE

KW - LUNG-FUNCTION

KW - EX-SMOKERS

KW - DILATION

U2 - 10.1080/17476348.2017.1389277

DO - 10.1080/17476348.2017.1389277

M3 - (Systematic) Review article

SN - 1747-6348

VL - 11

SP - 1021

EP - 1031

JO - Expert Review of Respiratory Medicine

JF - Expert Review of Respiratory Medicine

IS - 12

ER -

Endothelial function in patients with chronic obstructive pulmonary disease: a systematic review of studies using flow mediated dilatation

Abstract

Keywords

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