Endothelial Cell Dysfunction and Increased Cardiovascular Risk in Patients With Chronic Kidney Disease

C.C.F.M.J. Baaten; S. Vondenhoff; H. Noels

doi:10.1161/CIRCRESAHA.123.321752

Endothelial Cell Dysfunction and Increased Cardiovascular Risk in Patients With Chronic Kidney Disease

C.C.F.M.J. Baaten, S. Vondenhoff, H. Noels^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The endothelium is considered to be the gatekeeper of the vessel wall, maintaining and regulating vascular integrity. In patients with chronic kidney disease, protective endothelial cell functions are impaired due to the proinflammatory, prothrombotic and uremic environment caused by the decline in kidney function, adding to the increase in cardiovascular complications in this vulnerable patient population. In this review, we discuss endothelial cell functioning in healthy conditions and the contribution of endothelial cell dysfunction to cardiovascular disease. Further, we summarize the phenotypic changes of the endothelium in chronic kidney disease patients and the relation of endothelial cell dysfunction to cardiovascular risk in chronic kidney disease. We also review the mechanisms that underlie endothelial changes in chronic kidney disease and consider potential pharmacological interventions that can ameliorate endothelial health.

Original language	English
Pages (from-to)	970-992
Number of pages	23
Journal	Circulation Research
Volume	132
Issue number	8
DOIs	https://doi.org/10.1161/CIRCRESAHA.123.321752
Publication status	Published - 14 Apr 2023

Keywords

atherosclerosis
cardiovascular diseases
chronic kidney diseases
endothelial cells
vascular stiffness
FLOW-MEDIATED DILATION
LEFT-VENTRICULAR MASS
STAGE RENAL-DISEASE
C-REACTIVE PROTEIN
NITRIC-OXIDE SYNTHASE
CHRONIC HEART-FAILURE
SMOOTH-MUSCLE-CELLS
PULSE-WAVE VELOCITY
VASCULAR FUNCTION
INDOXYL SULFATE

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Cite this

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title = "Endothelial Cell Dysfunction and Increased Cardiovascular Risk in Patients With Chronic Kidney Disease",

abstract = "The endothelium is considered to be the gatekeeper of the vessel wall, maintaining and regulating vascular integrity. In patients with chronic kidney disease, protective endothelial cell functions are impaired due to the proinflammatory, prothrombotic and uremic environment caused by the decline in kidney function, adding to the increase in cardiovascular complications in this vulnerable patient population. In this review, we discuss endothelial cell functioning in healthy conditions and the contribution of endothelial cell dysfunction to cardiovascular disease. Further, we summarize the phenotypic changes of the endothelium in chronic kidney disease patients and the relation of endothelial cell dysfunction to cardiovascular risk in chronic kidney disease. We also review the mechanisms that underlie endothelial changes in chronic kidney disease and consider potential pharmacological interventions that can ameliorate endothelial health.",

keywords = "atherosclerosis, cardiovascular diseases, chronic kidney diseases, endothelial cells, vascular stiffness, FLOW-MEDIATED DILATION, LEFT-VENTRICULAR MASS, STAGE RENAL-DISEASE, C-REACTIVE PROTEIN, NITRIC-OXIDE SYNTHASE, CHRONIC HEART-FAILURE, SMOOTH-MUSCLE-CELLS, PULSE-WAVE VELOCITY, VASCULAR FUNCTION, INDOXYL SULFATE",

author = "C.C.F.M.J. Baaten and S. Vondenhoff and H. Noels",

note = "Funding Information: This work was supported by the Dutch Heart Foundation (2020T020 to C.C.F.M.J. Baaten); the START-Program of the Faculty of Medicine of the RWTH Aachen University (105/20 to C.C.F.M.J. Baaten and H. Noels); a grant from the Interdisciplinary Centre for Clinical Research within the faculty of Medicine at the RWTH Aachen University (PTD 1-12 to H. Noels); by the German Research Foundation (DFG) Project-ID 322900939–SFB/TRR219 (M-05 to H. Noels) and Project-ID 403224013—SFB 1382 (A-04 to H. Noels); and the German Center for Cardiovascular Research (DZHK-B23 to H. Noels). Further funding was provided by the “Else Kr{\"o}ner-Fresenius-Stiftung” (Project 2020_EKEA.60 to H. Noels). Publisher Copyright: {\textcopyright} 2023 The Authors. Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc.",

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AU - Baaten, C.C.F.M.J.

AU - Vondenhoff, S.

AU - Noels, H.

N1 - Funding Information: This work was supported by the Dutch Heart Foundation (2020T020 to C.C.F.M.J. Baaten); the START-Program of the Faculty of Medicine of the RWTH Aachen University (105/20 to C.C.F.M.J. Baaten and H. Noels); a grant from the Interdisciplinary Centre for Clinical Research within the faculty of Medicine at the RWTH Aachen University (PTD 1-12 to H. Noels); by the German Research Foundation (DFG) Project-ID 322900939–SFB/TRR219 (M-05 to H. Noels) and Project-ID 403224013—SFB 1382 (A-04 to H. Noels); and the German Center for Cardiovascular Research (DZHK-B23 to H. Noels). Further funding was provided by the “Else Kröner-Fresenius-Stiftung” (Project 2020_EKEA.60 to H. Noels). Publisher Copyright: © 2023 The Authors. Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc.

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N2 - The endothelium is considered to be the gatekeeper of the vessel wall, maintaining and regulating vascular integrity. In patients with chronic kidney disease, protective endothelial cell functions are impaired due to the proinflammatory, prothrombotic and uremic environment caused by the decline in kidney function, adding to the increase in cardiovascular complications in this vulnerable patient population. In this review, we discuss endothelial cell functioning in healthy conditions and the contribution of endothelial cell dysfunction to cardiovascular disease. Further, we summarize the phenotypic changes of the endothelium in chronic kidney disease patients and the relation of endothelial cell dysfunction to cardiovascular risk in chronic kidney disease. We also review the mechanisms that underlie endothelial changes in chronic kidney disease and consider potential pharmacological interventions that can ameliorate endothelial health.

AB - The endothelium is considered to be the gatekeeper of the vessel wall, maintaining and regulating vascular integrity. In patients with chronic kidney disease, protective endothelial cell functions are impaired due to the proinflammatory, prothrombotic and uremic environment caused by the decline in kidney function, adding to the increase in cardiovascular complications in this vulnerable patient population. In this review, we discuss endothelial cell functioning in healthy conditions and the contribution of endothelial cell dysfunction to cardiovascular disease. Further, we summarize the phenotypic changes of the endothelium in chronic kidney disease patients and the relation of endothelial cell dysfunction to cardiovascular risk in chronic kidney disease. We also review the mechanisms that underlie endothelial changes in chronic kidney disease and consider potential pharmacological interventions that can ameliorate endothelial health.

KW - atherosclerosis

KW - cardiovascular diseases

KW - chronic kidney diseases

KW - endothelial cells

KW - vascular stiffness

KW - FLOW-MEDIATED DILATION

KW - LEFT-VENTRICULAR MASS

KW - STAGE RENAL-DISEASE

KW - C-REACTIVE PROTEIN

KW - NITRIC-OXIDE SYNTHASE

KW - CHRONIC HEART-FAILURE

KW - SMOOTH-MUSCLE-CELLS

KW - PULSE-WAVE VELOCITY

KW - VASCULAR FUNCTION

KW - INDOXYL SULFATE

U2 - 10.1161/CIRCRESAHA.123.321752

DO - 10.1161/CIRCRESAHA.123.321752

M3 - Article

C2 - 37053275

SN - 0009-7330

VL - 132

SP - 970

EP - 992

JO - Circulation Research

JF - Circulation Research

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ER -