Endothelial and kidney function in women with a history of preeclampsia and healthy parous controls: A case control study

Veronica A. Lopes van Balen*, Julia J. Spaan, Tom Cornelis, Wieteke M. Heidema, Ralph R. Scholten, Marc E. A. Spaanderman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Web of Science)

Abstract

Introduction: Preeclampsia (PE) is a pregnancy related endothelial disease characterized by hypertension and albuminuria. Postpartum endothelial dysfunction often persists in these women. We postulate that in women with a history of PE reduced endothelial dependent vasodilation coincides with attenuated kidney function, as both reflect endothelial dysfunction. Methods: We assessed endothelial and kidney function in women with a history of PE (n = 79) and uncomplicated pregnancies (n = 49) at least 4 years postpartum. Women with hypertension, diabetes or kidney disease prior to pregnancy were excluded. Brachial artery flow mediated dilatation (FMD) was measured and analysed by a custom designed edge-detection and wall-tracking software. We measured albumin and creatinine levels in a 24-h urine sample and calculated glomerular filtration rate (GFR) by CKD-EPI. Results: Women with a history of PE had lower FMD but comparable GFR and albumin creatinine ratio (ACR) compared with controls. Independent of obstetric history, in both controls and women with a history of PE respectively, GFR (r = 0.19, p = 0.17 and r = 0.12, p = 0.29) and albumin creatinine ratio (r = 0.07, p = 0.62 and r = 0.06 p = 0.57) did not correlate with FMD. Conclusion: At least 4 years after pregnancy, women with a history of PE demonstrated decreased flow mediated dilatation when compared to healthy parous controls. In this study, decreased flow mediated dilation however did not coincide with decreased kidney function.
Original languageEnglish
Pages (from-to)71-76
Number of pages6
JournalMicrovascular Research
Volume116
DOIs
Publication statusPublished - 1 Mar 2018

Keywords

  • CARDIOVASCULAR RISK-FACTORS
  • FLOW-MEDIATED VASODILATION
  • STAGE RENAL-DISEASE
  • BRACHIAL-ARTERY
  • VASCULAR FUNCTION
  • DYSFUNCTION
  • AGE
  • DILATATION
  • PREGNANCY
  • HUMANS

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