Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78 (Glucose-Regulated Protein, 78 kDa)-Loaded Extracellular Vesicles

Malgorzata Furmanik, Rick van Gorp, Meredith Whitehead, Sadia Ahmad, Jayanta Bordoloi, Alexander Kapustin, Leon J Schurgers*, Catherine M Shanahan*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Web of Science)
Original languageEnglish
Pages (from-to)898-914
Number of pages17
JournalArteriosclerosis Thrombosis and Vascular Biology
Volume41
Issue number2
DOIs
Publication statusPublished - Feb 2021

Keywords

  • Activating Transcription Factor 4/genetics
  • Adolescent
  • Adult
  • Aged
  • Animals
  • Cells, Cultured
  • Disease Models, Animal
  • Endoplasmic Reticulum Stress/drug effects
  • Extracellular Vesicles/drug effects
  • Female
  • Gene Expression Regulation
  • Heat-Shock Proteins/genetics
  • Humans
  • Male
  • Middle Aged
  • Muscle, Smooth, Vascular/drug effects
  • Myocytes, Smooth Muscle/metabolism
  • Rats, Sprague-Dawley
  • Signal Transduction
  • Vascular Calcification/chemically induced
  • Warfarin/toxicity
  • Young Adult
  • eIF-2 Kinase/genetics
  • APOPTOSIS
  • ACTIVATION
  • OSTEOBLAST DIFFERENTIATION
  • MATRIX GLA-PROTEIN
  • vascular calcification
  • KINASE
  • arteries
  • INHIBITION
  • TRANSCRIPTION FACTOR 4
  • CALCIUM
  • MECHANISMS
  • warfarin
  • ARTERIAL CALCIFICATION
  • aging
  • endoplasmic reticulum

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