Endometrial preparation with Dienogest before hysteroscopic surgery: a systematic review

Antonio Simone Lagana*, Salvatore Giovanni Vitale, Vincenzo Muscia, Paola Rossetti, Massimo Buscema, Onofrio Triolo, Agnese Maria Chiara Rapisarda, Loretta Giunta, Vittorio Palmara, Roberta Granese, Helena Ban Frangez, Andrea Romano

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

54 Citations (Web of Science)

Abstract

Hysteroscopic surgery is considered the gold standard for the minimal invasive treatment of many endouterine diseases such as endometrial polyps or submucous myomas. Recently, many studies have evaluated the effect of preoperative administration of a number of drugs to reduce endometrial thickness and achieve important intraoperative advantages. The purpose of this systematic review is to summarize the available evidence about the use of Dienogest, an orally administrable progestin, for endometrial preparation before hysteroscopic surgery.

All studies published on this topic and indexed on PubMed/MEDLINE, Embase or Google scholar databases were retrieved and analysed.

We retrieved five studies about this topic. Considered together, the published data analyses allow us to conclude that Dienogest is effective in reducing the thickness of the endometrium, the severity of bleeding and also of operative time, with a lower number of side effects compared with other pharmacological preparations or no treatment.

Administration of Dienogest may be an effective and safe treatment for endometrial thinning before operative hysteroscopy. However, this conclusion is based on few reports and further studies to prove or disprove it are warranted.

Original languageEnglish
Pages (from-to)661-667
Number of pages7
JournalArchives of Gynecology and Obstetrics
Volume295
Issue number3
DOIs
Publication statusPublished - Mar 2017

Keywords

  • Dienogest
  • Hysteroscopy
  • Pretreatment
  • Endometrial thinning
  • PREOPERATIVE TREATMENT
  • OPERATIVE HYSTEROSCOPY
  • RANDOMIZED EVALUATION
  • ESTRADIOL VALERATE
  • COMPLICATIONS
  • WOMEN
  • PROGESTIN
  • EFFICACY
  • DANAZOL
  • DESOGESTREL

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