TY - JOUR
T1 - Endometrial preparation with Dienogest before hysteroscopic surgery
T2 - a systematic review
AU - Lagana, Antonio Simone
AU - Vitale, Salvatore Giovanni
AU - Muscia, Vincenzo
AU - Rossetti, Paola
AU - Buscema, Massimo
AU - Triolo, Onofrio
AU - Rapisarda, Agnese Maria Chiara
AU - Giunta, Loretta
AU - Palmara, Vittorio
AU - Granese, Roberta
AU - Frangez, Helena Ban
AU - Romano, Andrea
PY - 2017/3
Y1 - 2017/3
N2 - Hysteroscopic surgery is considered the gold standard for the minimal invasive treatment of many endouterine diseases such as endometrial polyps or submucous myomas. Recently, many studies have evaluated the effect of preoperative administration of a number of drugs to reduce endometrial thickness and achieve important intraoperative advantages. The purpose of this systematic review is to summarize the available evidence about the use of Dienogest, an orally administrable progestin, for endometrial preparation before hysteroscopic surgery.All studies published on this topic and indexed on PubMed/MEDLINE, Embase or Google scholar databases were retrieved and analysed.We retrieved five studies about this topic. Considered together, the published data analyses allow us to conclude that Dienogest is effective in reducing the thickness of the endometrium, the severity of bleeding and also of operative time, with a lower number of side effects compared with other pharmacological preparations or no treatment.Administration of Dienogest may be an effective and safe treatment for endometrial thinning before operative hysteroscopy. However, this conclusion is based on few reports and further studies to prove or disprove it are warranted.
AB - Hysteroscopic surgery is considered the gold standard for the minimal invasive treatment of many endouterine diseases such as endometrial polyps or submucous myomas. Recently, many studies have evaluated the effect of preoperative administration of a number of drugs to reduce endometrial thickness and achieve important intraoperative advantages. The purpose of this systematic review is to summarize the available evidence about the use of Dienogest, an orally administrable progestin, for endometrial preparation before hysteroscopic surgery.All studies published on this topic and indexed on PubMed/MEDLINE, Embase or Google scholar databases were retrieved and analysed.We retrieved five studies about this topic. Considered together, the published data analyses allow us to conclude that Dienogest is effective in reducing the thickness of the endometrium, the severity of bleeding and also of operative time, with a lower number of side effects compared with other pharmacological preparations or no treatment.Administration of Dienogest may be an effective and safe treatment for endometrial thinning before operative hysteroscopy. However, this conclusion is based on few reports and further studies to prove or disprove it are warranted.
KW - Dienogest
KW - Hysteroscopy
KW - Pretreatment
KW - Endometrial thinning
KW - PREOPERATIVE TREATMENT
KW - OPERATIVE HYSTEROSCOPY
KW - RANDOMIZED EVALUATION
KW - ESTRADIOL VALERATE
KW - COMPLICATIONS
KW - WOMEN
KW - PROGESTIN
KW - EFFICACY
KW - DANAZOL
KW - DESOGESTREL
U2 - 10.1007/s00404-016-4244-1
DO - 10.1007/s00404-016-4244-1
M3 - (Systematic) Review article
C2 - 27904953
SN - 0932-0067
VL - 295
SP - 661
EP - 667
JO - Archives of Gynecology and Obstetrics
JF - Archives of Gynecology and Obstetrics
IS - 3
ER -