Empagliflozin restores chronic kidney disease-induced impairment of endothelial regulation of cardiomyocyte relaxation and contraction

R.P. Juni, R. Al-Shama, D.W.D. Kuster, J. van der Velden, H.M. Hamer, M.G. Vervloet, E.C. Eringa, P. Koolwijk, V.W.M. van Hinsbergh*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1088-1101
Number of pages14
JournalKidney International
Volume99
Issue number5
DOIs
Publication statusPublished - 1 May 2021

Keywords

  • cardiomyocyte relaxation and contraction
  • chronic kidney disease
  • empagliflozin
  • endothelium-to-cardiomyocyte crosstalk
  • heart failure
  • mitochondrial oxidative damage
  • PRESERVED EJECTION FRACTION
  • ADVANCED GLYCATION ENDPRODUCTS
  • HEART-FAILURE
  • NITRIC-OXIDE
  • MITOCHONDRIAL FRAGMENTATION
  • RENAL DYSFUNCTION
  • INHIBITION
  • OUTCOMES
  • STRESS
  • RISK

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