Emerging evidence for CHFR as a cancer biomarker: from tumor biology to precision medicine

Sarah Derks, Arjen H. G. Cleven, Veerle Melotte, Kim M. Smits, Johann C. Brandes, Nilofer Azad, Wim van Criekinge, Adriaan P. de Bruine, James G. Herman, Manon van Engeland*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Web of Science)

Abstract

Novel insights in the biology of cancer have switched the paradigm of a "one-size-fits-all" cancer treatment to an individualized biology-driven treatment approach. In recent years, a diversity of biomarkers and targeted therapies has been discovered. Although these examples accentuate the promise of personalized cancer treatment, for most cancers and cancer subgroups no biomarkers and effective targeted therapy are available. The great majority of patients still receive unselected standard therapies with no use of their individual molecular characteristics. Better knowledge about the underlying tumor biology will lead the way toward personalized cancer treatment. In this review, we summarize the evidence for a promising cancer biomarker: checkpoint with forkhead and ring finger domains (CHFR). CHFR is a mitotic checkpoint and tumor suppressor gene, which is inactivated in a diverse group of solid malignancies, mostly by promoter CpG island methylation. CHFR inactivation has shown to be an indicator of poor prognosis and sensitivity to taxane-based chemotherapy. Here we summarize the current knowledge of altered CHFR expression in cancer, the impact on tumor biology and implications for personalized cancer treatment.
Original languageEnglish
Pages (from-to)161-171
JournalCancer and Metastasis Reviews
Volume33
Issue number1
DOIs
Publication statusPublished - Mar 2014

Keywords

  • CHFR promoter methylation
  • Predictive biomarker
  • Taxane sensitivity

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