Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders

Selin Aktan Guloksuz; Osman Abali; Esin Aktas Cetin; Sema Bilgic Gazioglu; Gunnur Deniz; Abdurrahman Yildirim; Ivana Kawikova; Sinan Guloksuz; James F. Leckman

doi:10.1590/1516-4446-2015-1843

Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders

Selin Aktan Guloksuz^*, Osman Abali, Esin Aktas Cetin, Sema Bilgic Gazioglu, Gunnur Deniz, Abdurrahman Yildirim, Ivana Kawikova, Sinan Guloksuz, James F. Leckman

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

34 Citations (Web of Science)

Abstract

Objective: To investigate plasma concentrations of S100B (a calcium-binding protein derived primarily from the glia) and inflammatory cytokines in children with autism and the relationship between S100B and cytokine concentrations.

Methods: Plasma levels of S100B, tumor necrosis factor alpha (TNF-alpha), interferon gamma, interleukin (IL)-1 beta, IL-4, IL-6, IL-10, and IL-17A were measured in 40 unmedicated children with autism and 35 normally developing healthy children. The severity of autism was assessed using the Childhood Autism Rating Scale (CARS).

Results: Concentrations of both S100B and TNF-alpha were higher in children with autism before and after adjusting for a priori-selected confounders (age, sex, and body mass index). S100B concentrations were higher in children with severe autism compared to children with mild-moderate autism. However, this association remained as a trend after adjusting for confounders. S100B concentrations correlated positively with TNF-alpha concentrations.

Conclusion: Our findings showing an increase in peripheral concentrations of S100B and TNF-alpha provide limited support to the hypothesis about the roles of altered immune function and S100B in autism spectrum disorder (ASD). Studies of larger numbers of well-characterized individuals with ASD are needed to clarify the potential role of the immune system in the pathophysiology of this disorder.

Original language	English
Pages (from-to)	195-200
Number of pages	6
Journal	Revista Brasileira de Psiquiatria
Volume	39
Issue number	3
DOIs	https://doi.org/10.1590/1516-4446-2015-1843
Publication status	Published - 2017

Keywords

Autism
inflammation
glia
tumor necrosis factor
cytokine
S100B
NF-KAPPA-B
MICROGLIAL ACTIVATION
PSYCHIATRIC-DISORDERS
REGRESSION
EXPRESSION
RESPONSES
CYTOKINE
INNATE
SYSTEM

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10.1590/1516-4446-2015-1843

Cite this

Guloksuz, S. A., Abali, O., Cetin, E. A., Gazioglu, S. B., Deniz, G., Yildirim, A., Kawikova, I., Guloksuz, S., & Leckman, J. F. (2017). Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders. Revista Brasileira de Psiquiatria, 39(3), 195-200. https://doi.org/10.1590/1516-4446-2015-1843

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title = "Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders",

abstract = "Objective: To investigate plasma concentrations of S100B (a calcium-binding protein derived primarily from the glia) and inflammatory cytokines in children with autism and the relationship between S100B and cytokine concentrations.Methods: Plasma levels of S100B, tumor necrosis factor alpha (TNF-alpha), interferon gamma, interleukin (IL)-1 beta, IL-4, IL-6, IL-10, and IL-17A were measured in 40 unmedicated children with autism and 35 normally developing healthy children. The severity of autism was assessed using the Childhood Autism Rating Scale (CARS).Results: Concentrations of both S100B and TNF-alpha were higher in children with autism before and after adjusting for a priori-selected confounders (age, sex, and body mass index). S100B concentrations were higher in children with severe autism compared to children with mild-moderate autism. However, this association remained as a trend after adjusting for confounders. S100B concentrations correlated positively with TNF-alpha concentrations.Conclusion: Our findings showing an increase in peripheral concentrations of S100B and TNF-alpha provide limited support to the hypothesis about the roles of altered immune function and S100B in autism spectrum disorder (ASD). Studies of larger numbers of well-characterized individuals with ASD are needed to clarify the potential role of the immune system in the pathophysiology of this disorder.",

keywords = "Autism, inflammation, glia, tumor necrosis factor, cytokine, S100B, NF-KAPPA-B, MICROGLIAL ACTIVATION, PSYCHIATRIC-DISORDERS, REGRESSION, EXPRESSION, RESPONSES, CYTOKINE, INNATE, SYSTEM",

author = "Guloksuz, {Selin Aktan} and Osman Abali and Cetin, {Esin Aktas} and Gazioglu, {Sema Bilgic} and Gunnur Deniz and Abdurrahman Yildirim and Ivana Kawikova and Sinan Guloksuz and Leckman, {James F.}",

year = "2017",

doi = "10.1590/1516-4446-2015-1843",

language = "English",

volume = "39",

pages = "195--200",

journal = "Revista Brasileira de Psiquiatria",

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TY - JOUR

T1 - Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders

AU - Guloksuz, Selin Aktan

AU - Abali, Osman

AU - Cetin, Esin Aktas

AU - Gazioglu, Sema Bilgic

AU - Deniz, Gunnur

AU - Yildirim, Abdurrahman

AU - Kawikova, Ivana

AU - Guloksuz, Sinan

AU - Leckman, James F.

PY - 2017

Y1 - 2017

N2 - Objective: To investigate plasma concentrations of S100B (a calcium-binding protein derived primarily from the glia) and inflammatory cytokines in children with autism and the relationship between S100B and cytokine concentrations.Methods: Plasma levels of S100B, tumor necrosis factor alpha (TNF-alpha), interferon gamma, interleukin (IL)-1 beta, IL-4, IL-6, IL-10, and IL-17A were measured in 40 unmedicated children with autism and 35 normally developing healthy children. The severity of autism was assessed using the Childhood Autism Rating Scale (CARS).Results: Concentrations of both S100B and TNF-alpha were higher in children with autism before and after adjusting for a priori-selected confounders (age, sex, and body mass index). S100B concentrations were higher in children with severe autism compared to children with mild-moderate autism. However, this association remained as a trend after adjusting for confounders. S100B concentrations correlated positively with TNF-alpha concentrations.Conclusion: Our findings showing an increase in peripheral concentrations of S100B and TNF-alpha provide limited support to the hypothesis about the roles of altered immune function and S100B in autism spectrum disorder (ASD). Studies of larger numbers of well-characterized individuals with ASD are needed to clarify the potential role of the immune system in the pathophysiology of this disorder.

AB - Objective: To investigate plasma concentrations of S100B (a calcium-binding protein derived primarily from the glia) and inflammatory cytokines in children with autism and the relationship between S100B and cytokine concentrations.Methods: Plasma levels of S100B, tumor necrosis factor alpha (TNF-alpha), interferon gamma, interleukin (IL)-1 beta, IL-4, IL-6, IL-10, and IL-17A were measured in 40 unmedicated children with autism and 35 normally developing healthy children. The severity of autism was assessed using the Childhood Autism Rating Scale (CARS).Results: Concentrations of both S100B and TNF-alpha were higher in children with autism before and after adjusting for a priori-selected confounders (age, sex, and body mass index). S100B concentrations were higher in children with severe autism compared to children with mild-moderate autism. However, this association remained as a trend after adjusting for confounders. S100B concentrations correlated positively with TNF-alpha concentrations.Conclusion: Our findings showing an increase in peripheral concentrations of S100B and TNF-alpha provide limited support to the hypothesis about the roles of altered immune function and S100B in autism spectrum disorder (ASD). Studies of larger numbers of well-characterized individuals with ASD are needed to clarify the potential role of the immune system in the pathophysiology of this disorder.

KW - Autism

KW - inflammation

KW - glia

KW - tumor necrosis factor

KW - cytokine

KW - S100B

KW - NF-KAPPA-B

KW - MICROGLIAL ACTIVATION

KW - PSYCHIATRIC-DISORDERS

KW - REGRESSION

KW - EXPRESSION

KW - RESPONSES

KW - CYTOKINE

KW - INNATE

KW - SYSTEM

U2 - 10.1590/1516-4446-2015-1843

DO - 10.1590/1516-4446-2015-1843

M3 - Article

C2 - 28099628

VL - 39

SP - 195

EP - 200

JO - Revista Brasileira de Psiquiatria

JF - Revista Brasileira de Psiquiatria

SN - 1516-4446

IS - 3

ER -