Elevated Activin A urine levels are predictors of intraventricular haemorrhage in preterm newborns

Andrea Sannia, Luc J. I. Zimmermann, Antonio W. D. Gavilanes, Hans J. Vles, Maria Grazia Calevo, Pasquale Florio, Diego Gazzolo*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Web of Science)


Aim Intraventricular haemorrhage (IVH) is the most common variety of cerebral haemorrhage and cause of neurological disabilities in preterm newborns. We evaluated the usefulness of urine Activin A concentrations for the early detection of perinatal IVH. Methods We conducted a case-control study on 100 preterm newborns (20 with IVH and 80 without IVH) in whom urine Activin A was measured at five predetermined time-points in the first 72h after birth. IVH diagnosis and the extension of the lesion were performed by ultrasound scanning within the first 72h and at 1week after birth, respectively. Results Urine Activin A in infants who developed IVH was significantly higher than in controls at all monitoring time-points (p
Original languageEnglish
Pages (from-to)E449-E454
JournalActa Paediatrica
Issue number10
Publication statusPublished - Oct 2013


  • Activin A
  • Biomarkers
  • Brain damage
  • IVH
  • Prematurity

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