Electroencephalography-based machine learning for cognitive profiling in Parkinson's disease: Preliminary results

Nacim Betrouni*, Arnaud Delval, Laurence Chaton, Luc Defebvre, Annelien Duits, Anja Moonen, Albert F. G. Leentjens, Kathy Dujardin

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Background Cognitive symptoms are common in patients with Parkinson's disease. Characterization of a patient's cognitive profile is an essential step toward the identification of predictors of cognitive worsening. Objective The aim of this study was to investigate the use of the combination of resting-state EEG and data-mining techniques to build characterization models. Methods Dense EEG data from 118 patients with Parkinson's disease, classified into 5 different groups according to the severity of their cognitive impairments, were considered. Spectral power analysis within 7 frequency bands was performed on the EEG signals. The obtained quantitative EEG features of 100 patients were mined using 2 machine-learning algorithms to build and train characterization models, namely, support vector machines and k-nearest neighbors models. The models were then blindly tested on data from 18 patients. Results The overall classification accuracies were 84% and 88% for the support vector machines and k-nearest algorithms, respectively. The worst classifications were observed for patients from groups with small sample sizes, corresponding to patients with the severe cognitive deficits. Whereas for the remaining groups for whom an accurate diagnosis was required to plan the future healthcare, the classification was very accurate. Conclusion These results suggest that EEG features computed from a daily clinical practice exploration modality in-that it is nonexpensive, available anywhere, and requires minimal cooperation from the patient-can be used as a screening method to identify the severity of cognitive impairment in patients with Parkinson's disease. (c) 2018 International Parkinson and Movement Disorder Society

Original languageEnglish
Pages (from-to)210-217
Number of pages8
JournalMovement Disorders
Volume34
Issue number2
DOIs
Publication statusPublished - Feb 2019

Keywords

  • characterization models
  • cognitive deficits
  • machine learning
  • quantitative EEG
  • IMPAIRMENT
  • DEMENTIA
  • PHENOTYPES
  • IMPACT
  • EEG

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