Electrical stimulation of the lower esophageal sphincter to address gastroesophageal reflux disease after sleeve gastrectomy

Yves Borbely*, Nicole Bouvy, Henning G. Schulz, Leonardo Rodriguez, Camilo Ortiz, Alejandro Nieponice

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Web of Science)


Background: Laparoscopic sleeve gastrectomy (LSG) can result in de novo and worsen preexisting gastroesophageal reflux disease (GERD). Post-LSG patients with GERD refractory to proton pump inhibitors (PPI) usually undergo more invasive, anatomy-altering Roux-en-Y gastric bypass surgery. Lower esophageal sphincter (LES) electrical stimulation (ES) preserves the anatomy and has been shown to improve outcomes in GERD patients. Objective: To evaluate the safety and efficacy of LES-ES in post-LSG patients with GERD not controlled with maximal PPI therapy. Setting: Prospective, international, multicenter registry. Methods: Patients with LSG-associated GERD partially responsive to PPI underwent LES-ES. GERD outcomes pre- and poststimulation were evaluated based on quality of life, esophageal acid exposure (after 6-12 mo), and PPI use. Results: Seventeen patients (11 female, 65%), treated at 6 centers between May 2014 and October, 2016 with a median follow-up of 12 months (range 6-24), received LES-ES. Median age was 48.6 years (interquartile range, 40.5-56), median body mass index 31.7 kg/m(2) (27.9-39.3). All patients were on at least daily PPI preoperatively; at last follow-up, 7 (41%) were completely off PPI, 5 (29%) took PPI on an intermittent basis, and 5 (29%) were on single-dose PPI. Median GERD- health-related quality of life scores improved from 34 (on-PPI, 25-41) at baseline to 9 (6-13) at last follow-up (off-PPI, P < .001). Percentage of time with esophageal pH <4 improved from 13.2% (3.7-30.7) to 5.8% (1.1-54.4), P = .01. Conclusion: LES-ES in post-LSG patients suffering from symptomatic, PPI-refractory GERD resulted in significant improvement of GERD-symptoms, esophageal acid exposure, and need for PPI. Preserving the post-LSG anatomy, it offers a valid option for patients unable or unwilling to undergo Roux-en-Y gastric bypass surgery. (C) 2018 American Society for Metabolic and Bariatric Surgery. All rights reserved.
Original languageEnglish
Pages (from-to)611-615
Number of pages5
JournalSurgery for Obesity and Related Diseases
Issue number5
Publication statusPublished - 1 May 2018


  • Electric stimulation therapy
  • Lower esophageal sphincter
  • Gastroesophageal reflux
  • Proton Pump Inhibitors
  • Quality of life
  • Sleeve gastrectomy
  • Bariatric surgery
  • Esophageal pH
  • Postgastrectomy syndromes
  • Prospective studies
  • RISK
  • GERD

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