TY - JOUR
T1 - Electrical stimulation of the fornix for the treatment of brain diseases
AU - Hescham, Sarah
AU - Temel, Yasin
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021
Y1 - 2021
N2 - Deep brain stimulation (DBS) has proven to be safe and effective for both hypo- and hyperkinetic movement disorders of basal ganglia origin, while its application to other neural pathways such as the circuit of Papez is under investigation. In particular, the fornix has gained interest as potential DBS target to decrease rates of cognitive decline, enhance memory, aid visuospatial memorization, and improve verbal recollection. While the exact mechanisms of action of fornix DBS are not completely understood, studies found enhanced hippocampal acetylcholine release, synaptic plasticity, and decreased inflammatory responses in cortex and hippocampus. Nevertheless, it is still premature to conclude that fornix DBS can be used in the treatment of cognitive disorders, and the field needs sound, preclinically tested, and disease-specific a posteriori hypotheses.
AB - Deep brain stimulation (DBS) has proven to be safe and effective for both hypo- and hyperkinetic movement disorders of basal ganglia origin, while its application to other neural pathways such as the circuit of Papez is under investigation. In particular, the fornix has gained interest as potential DBS target to decrease rates of cognitive decline, enhance memory, aid visuospatial memorization, and improve verbal recollection. While the exact mechanisms of action of fornix DBS are not completely understood, studies found enhanced hippocampal acetylcholine release, synaptic plasticity, and decreased inflammatory responses in cortex and hippocampus. Nevertheless, it is still premature to conclude that fornix DBS can be used in the treatment of cognitive disorders, and the field needs sound, preclinically tested, and disease-specific a posteriori hypotheses.
KW - Brain Diseases
KW - Deep Brain Stimulation
KW - Electric Stimulation
KW - Fornix, Brain
KW - Hippocampus
KW - Humans
U2 - 10.1016/B978-0-12-820107-7.00028-8
DO - 10.1016/B978-0-12-820107-7.00028-8
M3 - (Systematic) Review article
C2 - 34225947
SN - 0072-9752
VL - 180
SP - 447
EP - 454
JO - Handbook of Clinical Neurology
JF - Handbook of Clinical Neurology
ER -