Electrical modalities beyond pacing for the treatment of heart failure

Richard N. Cornelussen*, Vincent Splett, Ruth Nicholson Klepfer, Berthold Stegemann, Lilian Kornet, Frits W. Prinzen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


In this review, we report on electrical modalities, which do not fit the definition of pacemaker, but increase cardiac performance either by direct application to the heart (e. g., post-extrasystolic potentiation or non-excitatory stimulation) or indirectly through activation of the nervous system (e. g., vagal or sympathetic activation). The physiological background of the possible mechanisms of these electrical modalities and their potential application to treat heart failure are discussed.
Original languageEnglish
Pages (from-to)315-325
JournalHeart Failure Reviews
Issue number3
Publication statusPublished - May 2011


  • Pacing
  • Nervous system
  • (Electro) Physiology
  • Contractility
  • Heart failure

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