Electrical and Mechanical Ventricular Activation During Left Bundle Branch Block and Resynchronization

Marc Strik*, Francois Regoli, Angelo Auricchio, Frits Prinzen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Web of Science)


Cardiac resynchronization therapy (CRT) aims to treat selected heart failure patients suffering from conduction abnormalities with left bundle branch block (LBBB) as the culprit disease. LBBB remained largely underinvestigated until it became apparent that the amount of response to CRT was heterogeneous and that the therapy and underlying pathology were thus incompletely understood. In this review, current knowledge concerning activation in LBBB and during biventricular pacing will be explored and applied to current CRT practice, highlighting novel ways to better measure and treat the electrical substrate.
Original languageEnglish
Pages (from-to)117-126
JournalJournal of Cardiovascular Translational Research
Issue number2
Publication statusPublished - Apr 2012


  • Left bundle branch block
  • Cardiac resynchronization therapy
  • Electrical mapping

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