Efficient treatment allocation in 2x2 multicenter trials when costs and variances are heterogeneous

Francesca Lemme*, Gerard J. P. van Breukelen, Math J. J. M. Candel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Web of Science)
Original languageEnglish
Pages (from-to)12-27
Number of pages16
JournalStatistics in Medicine
Issue number1
Publication statusPublished - 15 Jan 2018


  • 2x2 factorial design
  • balanced design
  • heterogeneous costs
  • heterogeneous variance
  • multicenter trial

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