Efficient molecule discrimination in electron microscopy through an optimized orbital angular momentum sorter

F. Troiani, E. Rotunno*, S. Frabboni, R. B. G. Ravelli, P. J. Peters, E. Karimi, R. Grillo

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

We reformulate the single-molecule analysis in an electron microscope in terms of a quantum-state discrimination problem, and discuss its implementation through electron-beam shaping. Our approach relies on the use of new electron-optical elements to efficiently extract the "which-molecule" information from the state of each electron. The optimal observables are formally derived, and subsequently implemented by suitably designed phase elements in a generalized orbital angular momentum sorter. As a representative example, we simulate the discrimination between model proteins and benchmark the performance of the sorter against that of the best known real-space approach.

Original languageEnglish
Article number043510
Number of pages10
JournalPhysical Review A
Volume102
Issue number4
DOIs
Publication statusPublished - 12 Oct 2020

Keywords

  • CRYOELECTRON MICROSCOPY
  • PHASE-CONTRAST
  • LIGHT
  • PLATE

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