Efficacy of low-dose methotrexate treatment in birdshot chorioretinopathy.

A. Rothova, A.O. Norel, L.I. Los, T.T.J.M. Berendschot

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

PURPOSE:: To ascertain the effect of treatment with methotrexate (MTX) on the visual prognosis of birdshot chorioretinopathy (BSCR). METHODS:: Retrospective case series of 76 consecutive patients with HLA-A29-positive BSCR, of whom 46 were followed for at least 5 years and 18 for longer than 10 years. A review of the medical records of 76 patients with BSCR. Treatment regimens were subdivided into the following groups: 1) No systemic immunomodulatory treatment; 2) Treatment with systemic corticosteroids; and 3) Treatments which comprised MTX. First, we calculated eye-years for the different therapeutic regimens and second, we subdivided the patients according to their initial treatment regimen and assessed visual outcomes. RESULTS:: Mean visual acuity increased over time in the MTX-treated patients; remained unchanged in patients on systemic corticosteroids and decreased in the patients without systemic treatment (yearly change in LogMar -0.020, -0.034 and 0.028 with P = 0.034, P = 0.71 and P = 0.006 respectively). In the group treated initially with MTX, VA gradually increased in contrast to the remaining groups of patients (P = 0.003). CONCLUSION:: In this series, treatment comprising MTX showed better visual outcomes than the untreated patients and corticosteroid-based treatment regimens.
Original languageEnglish
Pages (from-to)1150-1155
Number of pages6
JournalRetina-The Journal of Retinal and Vitreous Diseases
Volume31
Issue number6
DOIs
Publication statusPublished - 1 Jan 2011

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