Efficacy of cisplatin-based immunochemotherapy plus alloSCT in high-risk chronic lymphocytic leukemia: final results of a prospective multicenter phase 2 HOVON study

M. van Gelder*, M. H. van Oers, W. G. Alemayehu, M. C. J. Abrahamse-Testroote, J. J. Cornelissen, M. E. Chamuleau, P. Zachee, M. Hoogendoorn, M. Nijland, E. J. Petersen, A. Beeker, G-J Timmers, L. Verdonck, M. Westerman, O. de Weerdt, A. P. Kater

*Corresponding author for this work

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Allogeneic stem cell transplantation (alloSCT) remains the only curative option for CLL patients. Whereas active disease at the time of alloSCT predicts poor outcome, no standard remission-induction regimen exists. We prospectively assessed outcome after cisplatin-containing immune-chemotherapy (R-DHAP) followed by alloSCT in 46 patients (median age 58 years) fulfilling modified European Society for Blood and Marrow Transplantation (EBMT) CLL Transplant Consensus criteria being refractory to or relapsed (R/R) = 3 cycles of R-DHAP and sixteen
Original languageEnglish
Pages (from-to)799-806
JournalBone Marrow Transplantation
Issue number6
Publication statusPublished - Jun 2016

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