Efficacy of a medical food in mild Alzheimer's disease: A randomized, controlled trial

Philip Scheltens*, Patrick J. G. H. Kamphuis, Frans R. J. Verhey, Marcel G. M. Olde Rikker, Richard J. Wurtman, David Wilkinson, Jos W R Twisk, Alexander Kurz

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

176 Citations (Web of Science)

Abstract

Objective: To investigate the effect of a medical food on cognitive function in people with mild Alzheimer's disease (AD). Methods: A total of 225 drug-naive AD patients participated in this randomized, double-blind controlled trial. Patients were randomized to active product, Souvenaid, or a control drink, taken once-daily for 12 weeks. Primary outcome measures were the delayed verbal recall task of the Wechsler Memory Scale-revised, and the 13-item modified Alzheimer's Disease Assessment Scale-cognitive subscale at week 12. Results: At 12 weeks, significant improvement in the delayed verbal recall task was noted in the active group compared with control (P=.021). Modified Alzheimer's Disease Assessment Scale-cognitive subscale and other outcome scores (e.g., Clinician Interview Based Impression of Change plus Caregiver Input, 12-item Neuropsychiatric Inventory, Alzheimer's disease Co-operative Study-Activities of Daily Living, Quality of Life in Alzheimer's Disease) were unchanged. The control group neither deteriorated nor improved. Compliance was excellent (95%) and the product was well tolerated. Conclusions: Supplementation with a medical food including phosphatide precursors and cofactors for 12 weeks improved memory (delayed verbal recall) in mild AD patients. This proof-of-concept study justifies further clinical trials.
Original languageEnglish
Pages (from-to)1-10
JournalAlzheimer's & Dementia
Volume6
Issue number1
DOIs
Publication statusPublished - Jan 2010

Keywords

  • Alzheimer's disease
  • Nutritional intervention
  • Synapse formation
  • Membrane phosphatide synthesis
  • B vitamins
  • Omega-3 fatty acids
  • Nucleotides
  • Uridine
  • Phospholipids
  • Choline
  • Antioxidants
  • ADAS-cog, delayed verbal recall
  • Medical food
  • Dietary management
  • Randomized clinical trial
  • Dementia

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