Effects of weight loss and long-term weight maintenance with diets varying in protein and glycemic index on cardiovascular risk factors: the diet, obesity, and genes (DiOGenes) study: a randomized, controlled trial.

O. Gogebakan, A. Kohl, M.A. Osterhoff, M.A. van Baak, S.A. Jebb, A. Papadaki, J.A. Martinez, T. Handjieva Darlenska, P. Hlavaty, M.O. Weickert, C. Holst, W.H. Saris, A. Astrup, A.F. Pfeiffer

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Abstract

Background-We sought to separately examine the effects of either weight loss or diets varying in protein content and glycemic index without further changes in body weight on cardiovascular risk factors within the Diet, Obesity, and Genes study (DiOGenes).

Methods and Results-DiOGenes is a pan-European controlled dietary intervention study in 932 overweight adults who first lost body weight on an 8-week low-calorie diet and were then randomized to 1 of 5 ad libitum diets for 26 weeks. The diets were either high or low protein or high or low glycemic index in 4 combinations or control. Weight loss (-11.23 kg; 95% confidence interval, -11.54 to -10.92; P

Conclusions-This large-scale intervention study clearly separates weight loss from dietary composition-related effects. Low-glycemic-index carbohydrates and, to a lesser extent, low-protein intake may specifically reduce low-grade inflammation and associated comorbidities in overweight/obese adults.

Original languageEnglish
Pages (from-to)2829-2838
Number of pages29
JournalCirculation
Volume124
Issue number25
DOIs
Publication statusPublished - 20 Dec 2011

Keywords

  • cardiovascular diseases
  • cardiovascular risk factors
  • C-reactive protein
  • diet
  • inflammation
  • C-REACTIVE PROTEIN
  • INSULIN-RESISTANCE
  • DISEASE RISK
  • YOUNG-ADULTS
  • LOAD
  • CARBOHYDRATE
  • RESTRICTION
  • HUMANS
  • LIPIDS
  • WOMEN

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