Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal

Dimosthenis Giamouridis, Meihua Gao, Ngai Chin Lai, Zhen Tan, Byung Chul Kim, Tracy Guo, Atsushi Miyanohara, Matthijs Blankesteijn, Erik Biessen, H. Kirk Hammond*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


UCn2 and UCn3 peptides have recently been infused to treat patients with heart failure (HF) but are limited by their short half-lives. A 1-time intravenous injection of virus vectors encoding UCn2 or UCn3 provided sustained increases in plasma concentrations of the peptides. This was associated with increases in both systolic and diastolic left ventricular (LV) function, mediated by increased LV SERCA2a expression and Ca2þ handling. UCn2, but not UCn3, gene transfer reduced fasting glucose and increased glucose disposal. These findings support UCn2 and UCn3 gene transfer as potential treatments for HF and indicate that UCn2 may be an optimal selection in patients with diabetes and HF.
Original languageEnglish
Pages (from-to)249-264
JournalJACC: Basic to Translational Science
Issue number2
Publication statusPublished - 2018

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