Effects of prehabilitation and rehabilitation including a home-based component on physical fitness, adherence, treatment tolerance, and recovery in patients with non-small cell lung cancer: A systematic review

Elisabeth J. Driessen*, Marieke E. Peeters, Bart C. Bongers, Huub A. Maas, Gerbern P. Bootsma, Nico L. van Meeteren, Maryska L. Janssen-Heijnen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

This systematic review aimed to examine physical fitness, adherence, treatment tolerance, and recovery for (p)rehabilitation including a home-based component for patients with non-small cell lung cancer (NSCLC). PRISMA and Cochrane guidelines were followed. Studies describing (home-based) prehabilitation or rehabilitation in patients with NSCLC were included from four databases (January 2000-April 2016, N= 11). Nine of ten rehabilitation studies and one prehabilitation study (437 NSCLC patients, mean age 59-72 years) showed significantly or clinically relevant improved physical fitness. Three (27%) assessed home-based training and eight (73%) combined training at home, inhospital (intramural) and/or at the physiotherapy practice/department (extramural). Six (55%) applied supervision of home-based components, and four (36%) a personalized training program. Adherence varied strongly (9-125% for exercises, 50-100% for patients). Treatment tolerance and recovery were heterogeneously reported. Although promising results of (p)rehabilitation for improving physical fitness were found (especially in case of supervision and personalization), adequately powered studies for home-based (p)rehabilitation are needed. (C) 2017 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)63-76
Number of pages14
JournalCritical Reviews in Oncology/Hematology
Volume114
DOIs
Publication statusPublished - Jun 2017

Keywords

  • Non-small cell lung cancer
  • Prehabilitation
  • Rehabilitation
  • Physical therapy
  • Compliance
  • Tolerance
  • Home
  • RANDOMIZED CONTROLLED-TRIAL
  • QUALITY-OF-LIFE
  • CLINICALLY IMPORTANT IMPROVEMENT
  • MINIMAL IMPORTANT DIFFERENCE
  • ESMO CONSENSUS CONFERENCE
  • FRAIL OLDER-ADULTS
  • SHUTTLE WALK TEST
  • EXERCISE INTERVENTION
  • PULMONARY REHABILITATION
  • FUNCTIONAL STATUS

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