TY - JOUR
T1 - Effects of physical exercise and body weight on disease-specific outcomes of people with rheumatic and musculoskeletal diseases (RMDs)
T2 - systematic reviews and meta-analyses informing the 2021 EULAR recommendations for lifestyle improvements in people with RMDs
AU - Gwinnutt, James M
AU - Wieczorek, Maud
AU - Cavalli, Giulio
AU - Balanescu, Andra
AU - Bischoff-Ferrari, Heike A
AU - Boonen, Annelies
AU - de Souza, Savia
AU - de Thurah, Annette
AU - Dorner, Thomas E
AU - Moe, Rikke Helene
AU - Putrik, Polina
AU - Rodríguez-Carrio, Javier
AU - Silva-Fernández, Lucía
AU - Stamm, Tanja
AU - Walker-Bone, Karen
AU - Welling, Joep
AU - Zlatković-Švenda, Mirjana I
AU - Guillemin, Francis
AU - Verstappen, Suzanne M M
N1 - © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.
PY - 2022/3/31
Y1 - 2022/3/31
N2 - BACKGROUND: A European League Against Rheumatism (EULAR) taskforce was convened to develop recommendations for lifestyle behaviours in rheumatic and musculoskeletal diseases (RMDs). This paper reviews the literature on the effects of physical exercise and body weight on disease-specific outcomes of people with RMDs.METHODS: Three systematic reviews were conducted to summarise evidence related to exercise and weight in seven RMDs: osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus, axial spondyloarthritis (axSpA), psoriatic arthritis, systemic sclerosis and gout. Systematic reviews and original studies were included if they assessed exercise or weight in one of the above RMDs, and reported results regarding disease-specific outcomes (eg, pain, function, joint damage). Systematic reviews were only included if published between 2013-2018. Search strategies were implemented in the Medline, Embase, Cochrane Library of systematic reviews and CENTRAL databases.RESULTS: 236 articles on exercise and 181 articles on weight were included. Exercise interventions resulted in improvements in outcomes such as pain and function across all the RMDs, although the size of the effect varied by RMD and intervention. Disease activity was not influenced by exercise, other than in axSpA. Increased body weight was associated with worse outcomes for the majority of RMDs and outcomes assessed. In general, study quality was moderate for the literature on exercise and body weight in RMDs, although there was large heterogeneity between studies.CONCLUSION: The current literature supports recommending exercise and the maintenance of a healthy body weight for people with RMDs.
AB - BACKGROUND: A European League Against Rheumatism (EULAR) taskforce was convened to develop recommendations for lifestyle behaviours in rheumatic and musculoskeletal diseases (RMDs). This paper reviews the literature on the effects of physical exercise and body weight on disease-specific outcomes of people with RMDs.METHODS: Three systematic reviews were conducted to summarise evidence related to exercise and weight in seven RMDs: osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus, axial spondyloarthritis (axSpA), psoriatic arthritis, systemic sclerosis and gout. Systematic reviews and original studies were included if they assessed exercise or weight in one of the above RMDs, and reported results regarding disease-specific outcomes (eg, pain, function, joint damage). Systematic reviews were only included if published between 2013-2018. Search strategies were implemented in the Medline, Embase, Cochrane Library of systematic reviews and CENTRAL databases.RESULTS: 236 articles on exercise and 181 articles on weight were included. Exercise interventions resulted in improvements in outcomes such as pain and function across all the RMDs, although the size of the effect varied by RMD and intervention. Disease activity was not influenced by exercise, other than in axSpA. Increased body weight was associated with worse outcomes for the majority of RMDs and outcomes assessed. In general, study quality was moderate for the literature on exercise and body weight in RMDs, although there was large heterogeneity between studies.CONCLUSION: The current literature supports recommending exercise and the maintenance of a healthy body weight for people with RMDs.
KW - ANKYLOSING-SPONDYLITIS PATIENTS
KW - Body Weight
KW - CLINICAL-PRACTICE GUIDELINES
KW - CORONARY-ARTERY-DISEASE
KW - Exercise
KW - HIGH-INTENSITY EXERCISE
KW - HOME-BASED EXERCISE
KW - Humans
KW - KNEE OSTEOARTHRITIS SYMPTOMS
KW - Life Style
KW - MODIFYING ANTIRHEUMATIC DRUGS
KW - Musculoskeletal Diseases/etiology
KW - OBESE OLDER-ADULTS
KW - QUALITY-OF-LIFE
KW - RANDOMIZED CONTROLLED-TRIAL
KW - Rheumatic Diseases/therapy
KW - Systematic Reviews as Topic
KW - arthritis
KW - epidemiology
KW - patient reported outcome measures
KW - physical therapy modalities
U2 - 10.1136/rmdopen-2021-002168
DO - 10.1136/rmdopen-2021-002168
M3 - (Systematic) Review article
C2 - 35361692
SN - 2056-5933
VL - 8
JO - RMD Open
JF - RMD Open
IS - 1
M1 - e002168
ER -