Effects of energy restriction on acute adrenoceptor and metabolic responses to exercise in obese subjects

K.P.G. Kempen*, W.H.M. Saris, J.M.G. Senden, P.P.C.A. Menheere, E.E. Blaak, M.A. van Baak

*Corresponding author for this work

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Effects of energy restriction on acute adrenoceptor and metabolic responses to exercise in obese subjects.

Kempen KP, Saris WH, Senden JM, Menheere PP, Blaak EE, van Baak MA.

Department of Human Biology, University of Limburg, Maastricht, The Netherlands.

This study was intended to investigate the effects of energy restriction on the acute responses of platelet alpha 2- and lymphocyte beta 2-adrenoceptors to exercise in obese female subjects. Seven obese females were restricted to a low-energy formula diet (2.0 MJ/day) for 4 wk. As result of the diet, there was a 7.8-kg weight loss. No significant changes could be detected in sleeping and resting metabolic rate expressed per kilogram fat-free mass. Basal venous glucose, insulin, and norepinephrine levels decreased as a result of the diet, whereas free fatty acid values increased. Before the diet, 60 min of exercise (45% peak mechanical power) caused no alteration in the density of lymphocyte beta 2-adrenoceptors. At the end of 4 wk of dieting, the density was significantly increased in response to exercise, together with a higher thermogenic and lipolytic response and decreased venous insulin levels. Energy restriction resulted in an increased basal platelet alpha 2-adrenoceptor density, whereas exercise did not modify density and affinity of platelet alpha 2-adrenoceptors. The results indicate that adrenoceptor numbers can be modulated by energy restriction in obesity. Modulation of adrenoceptor density may play a role in increased exercise-induced lipolysis during energy restriction
Original languageEnglish
Pages (from-to)E694-E701
JournalAmerican Journal of Physiology (Consolidated)
Issue number5
Publication statusPublished - 1 Jan 1994

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