Effects of Acetaldehyde on Intestinal Barrier Function

Elhaseen E. Elamin; Ad A. Masclee; Daisy M. Jonkers

doi:10.1016/B978-0-12-800773-0.00014-8

Effects of Acetaldehyde on Intestinal Barrier Function

Elhaseen E. Elamin^*, Ad A. Masclee, Daisy M. Jonkers

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

Abstract

Ethanol-induced epithelial barrier dysfunction increases the risk of inflammatory and carcinogenic diseases. Acetaldehyde, being a key metabolite of ethanol metabolism, is highly mutagenic and cytotoxic, but also has a strong potency to affect the apical junctional complex between epithelial cells. This chapter briefly outlines how acetaldehyde can reach and be generated in the small and large intestine, involving both host enzymes, and the intestinal microbiota. Then, the scientific evidence on effects of acetaldehyde on the intestinal barrier, and possible underlying mechanisms are summarized. Finally, modification of acetaldehyde-induced intestinal barrier dysfunction by various dietary components will be outlined. © 2016 Copyright

Original language	English
Title of host publication	Molecular Aspects of Alcohol and Nutrition: A Volume in the Molecular Nutrition Series
Editors	Vinood B. Patel
Publisher	Elsevier Inc.
Chapter	14
Pages	171-186
Number of pages	16
ISBN (Electronic)	9780128010037
ISBN (Print)	9780128007730
DOIs	https://doi.org/10.1016/B978-0-12-800773-0.00014-8
Publication status	Published - 1 Jan 2016

Keywords

Acetaldehyde
Barrier
Epithelium
Intestine
Tight junction

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10.1016/B978-0-12-800773-0.00014-8

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abstract = "Ethanol-induced epithelial barrier dysfunction increases the risk of inflammatory and carcinogenic diseases. Acetaldehyde, being a key metabolite of ethanol metabolism, is highly mutagenic and cytotoxic, but also has a strong potency to affect the apical junctional complex between epithelial cells. This chapter briefly outlines how acetaldehyde can reach and be generated in the small and large intestine, involving both host enzymes, and the intestinal microbiota. Then, the scientific evidence on effects of acetaldehyde on the intestinal barrier, and possible underlying mechanisms are summarized. Finally, modification of acetaldehyde-induced intestinal barrier dysfunction by various dietary components will be outlined. {\textcopyright} 2016 Copyright",

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T1 - Effects of Acetaldehyde on Intestinal Barrier Function

AU - Elamin, Elhaseen E.

AU - Masclee, Ad A.

AU - Jonkers, Daisy M.

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N2 - Ethanol-induced epithelial barrier dysfunction increases the risk of inflammatory and carcinogenic diseases. Acetaldehyde, being a key metabolite of ethanol metabolism, is highly mutagenic and cytotoxic, but also has a strong potency to affect the apical junctional complex between epithelial cells. This chapter briefly outlines how acetaldehyde can reach and be generated in the small and large intestine, involving both host enzymes, and the intestinal microbiota. Then, the scientific evidence on effects of acetaldehyde on the intestinal barrier, and possible underlying mechanisms are summarized. Finally, modification of acetaldehyde-induced intestinal barrier dysfunction by various dietary components will be outlined. © 2016 Copyright

AB - Ethanol-induced epithelial barrier dysfunction increases the risk of inflammatory and carcinogenic diseases. Acetaldehyde, being a key metabolite of ethanol metabolism, is highly mutagenic and cytotoxic, but also has a strong potency to affect the apical junctional complex between epithelial cells. This chapter briefly outlines how acetaldehyde can reach and be generated in the small and large intestine, involving both host enzymes, and the intestinal microbiota. Then, the scientific evidence on effects of acetaldehyde on the intestinal barrier, and possible underlying mechanisms are summarized. Finally, modification of acetaldehyde-induced intestinal barrier dysfunction by various dietary components will be outlined. © 2016 Copyright

KW - Acetaldehyde

KW - Barrier

KW - Epithelium

KW - Intestine

KW - Tight junction

U2 - 10.1016/B978-0-12-800773-0.00014-8

DO - 10.1016/B978-0-12-800773-0.00014-8

M3 - Chapter

SN - 9780128007730

SP - 171

EP - 186

BT - Molecular Aspects of Alcohol and Nutrition: A Volume in the Molecular Nutrition Series

A2 - Patel, Vinood B.

PB - Elsevier Inc.

ER -

Effects of Acetaldehyde on Intestinal Barrier Function

Abstract

Keywords

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