Effects of a proton-pump inhibitor in cystic fibrosis.

T.M. Tran, A.M. van den Neucker, J.J.E. Hendriks, Ph. Forget

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Abstract

Department of Pediatrics, University Hospital of Maastricht, The Netherlands.

Most children with cystic fibrosis (CF) show persisting steatorrhoea even when treated with pancreatic enzyme. As a low duodenal pH could be responsible for this persisting fat loss, we evaluated the effects of a proton-pump inhibitor (lansoprazole) on both steatorrhoea and growth parameters in 15 CF patients, aged 3.1-22.6 y. Acid steatocrit, anthropometry and dual-energy X-ray absorptiometry were used to evaluate steatorrhoea and the nutritional status before, during and 3 months after stopping lansoprazole treatment (15 mg/d for 3 months). Mean +/- SD acid steatocrit values decreased from 37.1 +/- 8.8% to 28.5 +/- 10.6% (p = 0.02). Significant mean Z-score improvements were found for weight (+0.14; p = 0.02), height (+0.15; p = 0.03), subscapular (+0.61; p = 0.003), supra-iliac (+0.8; p = 0.002) and the sum of the four measured skinfolds (+0.61; p = 0.002). Z-scores deteriorated again after stopping lansoprazole. Fat mass and bone mineral content increased significantly on lansoprazole (p = 0.008 and p = 0.005, respectively). We conclude that lansoprazole as adjuvant therapy significantly improves both steatorrhoea and the nutritional status in CF children who maintain steatorrhoea while on pancreatic enzymes.
Original languageEnglish
Pages (from-to)553-558
Number of pages6
JournalActa Paediatrica
Volume87
Issue number5
DOIs
Publication statusPublished - 1 Jan 1998

Cite this

Tran, T. M., van den Neucker, A. M., Hendriks, J. J. E., & Forget, P. (1998). Effects of a proton-pump inhibitor in cystic fibrosis. Acta Paediatrica, 87(5), 553-558. https://doi.org/10.1080/08035259850158281