@article{2af0b9a9e393411aa2d387bdb1e45509,
title = "Effectiveness of lifestyle intervention in subgroups of obese infertile women: a subgroup analysis of a RCT",
abstract = "STUDY QUESTION: Do age, ovulatory status, severity of obesity and body fat distribution affect the effectiveness of lifestyle intervention in obese infertile women? SUMMARY ANSWER: We did not identify a subgroup in which lifestyle intervention increased the healthy live birth rate however it did increase the natural conception rate in anovulatory obese infertile women. WHAT IS KNOWN ALREADY: Obese women are at increased risk of infertility and are less likely to conceive after infertility treatment. We previously demonstrated that a 6-month lifestyle intervention preceding infertility treatment did not increase the rate of healthy live births (vaginal live birth of a healthy singleton at term) within 24 months of follow-up as compared to prompt infertility treatment in obese infertile women. Natural conceptions occurred more frequently in women who received a 6-month lifestyle intervention preceding infertility treatment. STUDY DESIGN, SIZE, DURATION: This is a secondary analysis of a multicentre RCT (randomized controlled trial), the LIFEstyle study. Between 2009 and 2012, 577 obese infertile women were randomly assigned to a 6-month lifestyle intervention followed by infertility treatment (intervention group) or to prompt infertility treatment (control group). Subgroups were predefined in the study protocol, based on frequently used cut-off values in the literature: age (>= 36 or = 35 or = 0.8 or ",
keywords = "anovulation, infertility, lifestyle intervention, obesity, subgroup analysis, natural conception",
author = "{van Oers}, {A. M.} and H. Groen and Mutsaerts, {M. A. Q.} and Burggraaff, {J. M.} and Kuchenbecker, {W. K. H.} and Perquin, {D. A. M.} and Koks, {C. A. M.} and {van Golde}, R. and Kaaijk, {E. M.} and Schierbeek, {J. M.} and Oosterhuis, {G. J. E.} and Broekmans, {F. J.} and Vogel, {N. E. A.} and Land, {J. A.} and Mol, {B. W. J.} and A. Hoek",
year = "2016",
month = dec,
doi = "10.1093/humrep/dew252",
language = "English",
volume = "31",
pages = "2704--2713",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "Oxford University Press",
number = "12",
}