Effectiveness of bedside investigations to diagnose peripheral artery disease among people with diabetes mellitus: a systematic review

J.R. Brownrigg, R.J. Hinchliffe, J. Apelqvist, E.J. Boyko, R. Fitridge, J.L. Mills, J. Reekers, C.P. Shearman, R.E. Zierler, N.C. Schaper, The International Working Group on the Diabetic Foot

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5 Citations (Scopus)

Abstract

Non-invasive tests for the detection of peripheral artery disease (PAD) among individuals with diabetes mellitus are important to estimate the risk of amputation, ulceration, wound healing and the presence of cardiovascular disease, yet there are no consensus recommendations to support a particular diagnostic modality over another and to evaluate the performance of index non-invasive diagnostic tests against reference standard imaging techniques (magnetic resonance angiography, computed tomography angiography, digital subtraction angiography and colour duplex ultrasound) for the detection of PAD among patients with diabetes. Two reviewers independently screened potential studies for inclusion and extracted study data. Eligible studies evaluated an index test for PAD against a reference test. An assessment of methodological quality was performed using the quality assessment for diagnostic accuracy studies instrument. Of the 6629 studies identified, ten met the criteria for inclusion. In these studies, the patients had a median age of 60-74 years and a median duration of diabetes of 9-24years. Two studies reported exclusively on patients with symptomatic (ulcerated/infected) feet, two on patients with asymptomatic (intact) feet only, and the remaining six on patients both with and without foot ulceration. Ankle brachial index (ABI) was the most widely assessed index test. Overall, the positive likelihood ratio and negative likelihood ratio (NLR) of an ABI threshold

Original languageEnglish
Pages (from-to)119-127
Number of pages9
JournalDiabetes/Metabolism Research and Reviews
Volume32
Issue numbersuppl. 1
Early online date5 Sep 2015
DOIs
Publication statusPublished - Jan 2016

Keywords

  • peripheral artery disease
  • diagnosis
  • diabetes
  • investigations
  • VASCULAR-DISEASE
  • FOOT
  • INDEX
  • PREVALENCE
  • PRESSURE
  • HEALTH
  • ANGIOGRAPHY
  • ISCHEMIA
  • RISK

Cite this

Brownrigg, J. R., Hinchliffe, R. J., Apelqvist, J., Boyko, E. J., Fitridge, R., Mills, J. L., Reekers, J., Shearman, C. P., Zierler, R. E., Schaper, N. C., & International Working Group on the Diabetic Foot, T. (2016). Effectiveness of bedside investigations to diagnose peripheral artery disease among people with diabetes mellitus: a systematic review. Diabetes/Metabolism Research and Reviews, 32(suppl. 1), 119-127. https://doi.org/10.1002/dmrr.2703