Effect of Vagus Nerve Integrity on Short and Long-Term Efficacy of Antireflux Surgery

S. Van Rijn, N. F. Rinsma, M. Y. A. van Herwaarden-Lindeboom, J. Ringers, H. G. Gooszen, P. J. J. van Rijn, R. A. Veenendaal, J. M. Conchillo, N. D. Bouvy, Adrian A. M. Masclee*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


OBJECTIVES: Vagus nerve injury is a feared complication of antireflux surgery (ARS) that may negatively affect reflux control. The aim of the present prospective study was to evaluate short-term and long-term impact of vagus nerve injury, evaluated by pancreatic polypeptide response to insulin-induced hypoglycemia (PP-IH), on the outcome of ARS. METHODS: In the period from 1990 until 2000, 125 patients with gastroesophageal reflux disease (GERD) underwent ARS at a single center. Before and 6 months after surgery, vagus nerve integrity testing (PP-IH), 24-h pH-monitoring, gastric emptying, and reflux-associated symptoms were evaluated. In 2014, 14-25 years after surgery, 110 patients were contacted again for evaluation of long-term symptomatic outcome using two validated questionnaires (Gastrointestinal Symptom Rating Scale (GSRS) and GERD-Health Related Quality of Life (HRQL)). RESULTS: Short-term follow-up: vagus nerve injury (PP peak
Original languageEnglish
Pages (from-to)508-515
JournalAmerican Journal of Gastroenterology
Issue number4
Publication statusPublished - Apr 2016


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