Effect of TNP-470 (AGM-1470) on the growth of rat rhabdomyosarcoma tumors of different sizes

W Landuyt; J Theys; S Nuyts; M Drijkoningen; J Fowler; A Reijnders; S Liekens; J Neyts; E de Bruijn; J Anne; P Lambin

doi:10.1081/CNV-100000073

Effect of TNP-470 (AGM-1470) on the growth of rat rhabdomyosarcoma tumors of different sizes

W Landuyt^*
, J Theys
, S Nuyts
, M Drijkoningen
, J Fowler
, A Reijnders
, S Liekens
, J Neyts
, E de Bruijn
, J Anne
, P Lambin

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Potential anticancer therapy with the fumagillin analog TNP-470 was investigated in the present project using subcutaneously growing rhabdomyosarcomas in rats. Specifically, influences of different tumor sizes at the start of treatment as well as dose/schedules were evaluated with this angiogenesis inhibitor The results show a significant (p = less than or equal to0.01) reduction of the growth rare, even for relatively large-sized (>7 cm(3)) tumors, when 50 m/kg TNP-470 was used every other day for up to 3 or 5 injections. With 30 mg/kg TNP-470 injections, effects were seen only with tumors measuring

Original language	English
Pages (from-to)	35-40
Number of pages	6
Journal	Cancer Investigation
Volume	19
Issue number	1
DOIs	https://doi.org/10.1081/CNV-100000073
Publication status	Published - 2001
Externally published	Yes

Keywords

ANGIOGENESIS INHIBITOR
METASTASIS
FUMAGILLIN
CANCER

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10.1081/CNV-100000073

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abstract = "Potential anticancer therapy with the fumagillin analog TNP-470 was investigated in the present project using subcutaneously growing rhabdomyosarcomas in rats. Specifically, influences of different tumor sizes at the start of treatment as well as dose/schedules were evaluated with this angiogenesis inhibitor The results show a significant (p = less than or equal to0.01) reduction of the growth rare, even for relatively large-sized (>7 cm(3)) tumors, when 50 m/kg TNP-470 was used every other day for up to 3 or 5 injections. With 30 mg/kg TNP-470 injections, effects were seen only with tumors measuring",

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doi = "10.1081/CNV-100000073",

language = "English",

volume = "19",

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T1 - Effect of TNP-470 (AGM-1470) on the growth of rat rhabdomyosarcoma tumors of different sizes

AU - Landuyt, W

AU - Theys, J

AU - Nuyts, S

AU - Drijkoningen, M

AU - Fowler, J

AU - Reijnders, A

AU - Liekens, S

AU - Neyts, J

AU - de Bruijn, E

AU - Anne, J

AU - Lambin, P

PY - 2001

Y1 - 2001

N2 - Potential anticancer therapy with the fumagillin analog TNP-470 was investigated in the present project using subcutaneously growing rhabdomyosarcomas in rats. Specifically, influences of different tumor sizes at the start of treatment as well as dose/schedules were evaluated with this angiogenesis inhibitor The results show a significant (p = less than or equal to0.01) reduction of the growth rare, even for relatively large-sized (>7 cm(3)) tumors, when 50 m/kg TNP-470 was used every other day for up to 3 or 5 injections. With 30 mg/kg TNP-470 injections, effects were seen only with tumors measuring

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KW - ANGIOGENESIS INHIBITOR

KW - METASTASIS

KW - FUMAGILLIN

KW - CANCER

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DO - 10.1081/CNV-100000073

M3 - Article

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VL - 19

SP - 35

EP - 40

JO - Cancer Investigation

JF - Cancer Investigation

IS - 1

ER -

Effect of TNP-470 (AGM-1470) on the growth of rat rhabdomyosarcoma tumors of different sizes

Abstract

Keywords

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