Background sibutramine is a tertiary amine that has been shown to induce dose-dependent weight loss and to enhance the effects of a low-calorie diet for up to a year. We did a randomised, double-blind trial to assess the usefulness of sibutramine in maintaining substantial weight loss over 2 years.
James, W. P. T., Astrup, A. V., Finer, N., Hilsted, J., Kopelman, P., Rossner, S., Saris, W. H. M., van Gaal, L. F., & the STORM Study, G. (2000). Effect of sibutramine on weight maintenance after weight loss: a randomized trial. Lancet, 23-30(356), 2119-2125. https://doi.org/10.1016/S0140-6736(00)03491-7