Purpose: The ergogenic effect of acute beta 2-adrenergic agonist administration in nonasthmatic individuals has not been clearly demonstrated Therefore, the acute effects of oral administration of the beta 2-adrenergic agonist salbutamol (4 mg) on muscle strength and endurance performance were studied in 16 nonasthmatic men in a double-blind randomized cross-over study. Methods: Peak expiratory flow (Mini Wright Peakflowmeter), isokinetic strength of the knee extensors and knee flexors at four angular velocities (Cybex II dynamometer), and endurance performance in a cycle ergometer test until exhaustion at 70% of maximal workload were measured. Results: Peak expiratory flow increased from 601 +/- 67 L.min(-1) to 629 +/- 64 L.min(-1) after salbutamol (P <0.05). Peak torque was higher after salbutamol than after placebo (4.4% for the knee extensors, 4.9% for the knee flexors) (P <0.05). Mean endurance time increased from 3039 +/- 1031 s after placebo to 3439 +/- 1287 s after salbutamol (P = 0.19). When four subjects complaining about adverse side effects were excluded from the analysis, the increase in endurance time (729 +/- 1007 s or 29%) was statistically significant (P <0.05). Salbutamol did not affect (V)over dotO(2), respiratory exchange ratio, heart rate, and plasma free fatty acid and glycerol concentration during exercise; plasma lactate and potassium concentrations were increased (P <0.05). Conclusions: Under the conditions of this study, oral salbutamol appears to be an effective ergogenic aid in nonasthmatic individuals not experiencing adverse side effects.
van Baak, M. A., Mayer, L. H. J., Kempinski, R. E. S., & Hartgens, F. (2000). Effect of salbutamol on muscle strength and endurance performance in nonasthmatic men. Medicine and Science in Sports and Exercise, 32(7), 1300-1306. https://doi.org/10.1097/00005768-200007000-00018