Effect of oral glucose on leucine turnover in human subjects at rest and during exercise at two levels of dietary protein

J.L. Bowtell, G.P. Leese, K. Smith, P.W. Watt, A. Nevill, O. Rooyackers, A.J.M. Wagenmakers, M.J. Rennie

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Abstract

1. The aim of this study was to determine the effect of glucose supplementation on leucine turnover during and after exercise and whether variation in the previous dietary protein content modulated this effect. 2. Postabsorptive subjects received a primed constant [1-C-13,N-15]leucine infusion for 6 h, after previous consumption of a high (1.8 g kg(-1) day(-1) HP, n = 16) or low (0.7 g kg(-1) day(-1), LP, n = 16) protein diet for 7 days. The subjects were studied at rest; during 2 h of exercise, during which half of the subjects from each dietary protocol received 0.75 g kg(-1) h(-1) glucose (HP + G, LP + G) and the other half received water (HP + W, LP + W); then again for 2 h of rest. 3. Glucose supplementation suppressed leucine oxidation (P availability.
Original languageEnglish
Pages (from-to)271-281
Number of pages10
JournalJournal of Physiology
Volume525
Issue number1
DOIs
Publication statusPublished - 1 Jan 2000

Cite this

Bowtell, J. L., Leese, G. P., Smith, K., Watt, P. W., Nevill, A., Rooyackers, O., Wagenmakers, A. J. M., & Rennie, M. J. (2000). Effect of oral glucose on leucine turnover in human subjects at rest and during exercise at two levels of dietary protein. Journal of Physiology, 525(1), 271-281. https://doi.org/10.1111/j.1469-7793.2000.00271.x