TY - JOUR
T1 - Effect of obesity on gastrointestinal transit, pressure and pH using a wireless motility capsule
AU - Steenackers, N.
AU - Wauters, L.
AU - Van der Schueren, B.
AU - Augustijns, P.
AU - Falony, G.
AU - Koziolek, M.
AU - Lannoo, M.
AU - Mertens, A.
AU - Meulemans, A.
AU - Raes, J.
AU - Vangoitsenhoven, R.
AU - Vieira-Silva, S.
AU - Weitschies, W.
AU - Matthys, C.
AU - Vanuytsel, T.
PY - 2021/10
Y1 - 2021/10
N2 - Background: Despite the increasing prevalence and medical burden of obesity, the understanding of gastrointestinal physiology in obesity is scarce, which hampers drug development.Aim: To investigate the effect of obesity and food intake on gastrointestinal transit, pressure and pH.Material and methods: An exploratory cross-sectional study using a wireless motility capsule (SmartPill (c)) was performed in 11 participants with obesity and 11 age- and gender-matched participants with normal weight (group) in fasted and fed state (visit). During the first visit, the capsule was ingested after an overnight fast. During a second visit, the capsule was ingested after a nutritional drink to simulate fed state. Linear mixed models were constructed to compare segmental gastrointestinal transit, pressure and pH between groups (obesity or control) and within every group (fasted or fed).Results: Food intake slowed gastric emptying in both groups (both P < 0.0001), though food-induced gastric contractility was higher in participants with obesity compared to controls (P = 0.02). In the small intestine, a higher contractility (P = 0.001), shorter transit (P = 0.04) and lower median pH (P = 0.002) was observed in participants with obesity compared to controls. No differences were observed for colonic measurements.Conclusion: Obesity has a profound impact on gastrointestinal physiology, which should be taken into account for drug development.
AB - Background: Despite the increasing prevalence and medical burden of obesity, the understanding of gastrointestinal physiology in obesity is scarce, which hampers drug development.Aim: To investigate the effect of obesity and food intake on gastrointestinal transit, pressure and pH.Material and methods: An exploratory cross-sectional study using a wireless motility capsule (SmartPill (c)) was performed in 11 participants with obesity and 11 age- and gender-matched participants with normal weight (group) in fasted and fed state (visit). During the first visit, the capsule was ingested after an overnight fast. During a second visit, the capsule was ingested after a nutritional drink to simulate fed state. Linear mixed models were constructed to compare segmental gastrointestinal transit, pressure and pH between groups (obesity or control) and within every group (fasted or fed).Results: Food intake slowed gastric emptying in both groups (both P < 0.0001), though food-induced gastric contractility was higher in participants with obesity compared to controls (P = 0.02). In the small intestine, a higher contractility (P = 0.001), shorter transit (P = 0.04) and lower median pH (P = 0.002) was observed in participants with obesity compared to controls. No differences were observed for colonic measurements.Conclusion: Obesity has a profound impact on gastrointestinal physiology, which should be taken into account for drug development.
KW - Food effect
KW - Gastrointestinal pH
KW - Gastrointestinal physiology
KW - Gastrointestinal pressure
KW - Gastrointestinal transit time
KW - Obesity
KW - Wireless motility capsule
U2 - 10.1016/j.ejpb.2021.07.002
DO - 10.1016/j.ejpb.2021.07.002
M3 - Article
C2 - 34273543
SN - 0939-6411
VL - 167
SP - 1
EP - 8
JO - European Journal of Pharmaceutics and Biopharmaceutics
JF - European Journal of Pharmaceutics and Biopharmaceutics
ER -