Effect of Lenient Versus Strict Rate Control on Cardiac Remodeling in Patients With Atrial Fibrillation

Marcelle D. Smit; Harry J. G. M. Crijns; Jan G. P. Tijssen; Hans L. Hillege; Marco Alings; Ype S. Tuininga; Hessel F. Groenveld; Maarten P. Van den Berg; Dirk J. van Veldhuisen; Isabelle C. Van Gelder

doi:10.1016/j.jacc.2011.04.030

Effect of Lenient Versus Strict Rate Control on Cardiac Remodeling in Patients With Atrial Fibrillation

Marcelle D. Smit, Harry J. G. M. Crijns, Jan G. P. Tijssen, Hans L. Hillege, Marco Alings, Ype S. Tuininga, Hessel F. Groenveld, Maarten P. Van den Berg, Dirk J. van Veldhuisen, Isabelle C. Van Gelder^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objectives The aim of this study was to evaluate echocardiographic remodeling in permanent atrial fibrillation (AF) patients treated with either lenient or strict rate control. Background It is unknown whether in permanent AF, lenient rate control is associated with more adverse cardiac remodeling than strict rate control. Methods Echocardiography was conducted at baseline and at follow-up in 517 patients included in the RACE II (RAte Control Efficacy in permanent atrial fibrillation II) trial. Echocardiographic parameters were compared between patients randomized to lenient rate control (n = 261) or strict rate control (n = 256). Results Baseline echocardiographic parameters were comparable between patients randomized to lenient and strict rate control. Between baseline and follow-up, significant adverse atrial or ventricular remodeling was not observed in either group. There were also no significant differences in atrial and ventricular remodeling between patients who continuously had heart rates between 80 and 110 beats/min and patients who continuously had heart rates

Original language	English
Pages (from-to)	942-949
Journal	Journal of the American College of Cardiology
Volume	58
Issue number	9
DOIs	https://doi.org/10.1016/j.jacc.2011.04.030
Publication status	Published - 23 Aug 2011

Keywords

atrial fibrillation
echocardiography
rate control
remodeling

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Smit, M. D., Crijns, H. J. G. M., Tijssen, J. G. P., Hillege, H. L., Alings, M., Tuininga, Y. S., Groenveld, H. F., Van den Berg, M. P., van Veldhuisen, D. J., & Van Gelder, I. C. (2011). Effect of Lenient Versus Strict Rate Control on Cardiac Remodeling in Patients With Atrial Fibrillation. Journal of the American College of Cardiology, 58(9), 942-949. https://doi.org/10.1016/j.jacc.2011.04.030

@article{57d6f8b508c6499cb66fd95ff8b52d6f,

title = "Effect of Lenient Versus Strict Rate Control on Cardiac Remodeling in Patients With Atrial Fibrillation",

abstract = "Objectives The aim of this study was to evaluate echocardiographic remodeling in permanent atrial fibrillation (AF) patients treated with either lenient or strict rate control. Background It is unknown whether in permanent AF, lenient rate control is associated with more adverse cardiac remodeling than strict rate control. Methods Echocardiography was conducted at baseline and at follow-up in 517 patients included in the RACE II (RAte Control Efficacy in permanent atrial fibrillation II) trial. Echocardiographic parameters were compared between patients randomized to lenient rate control (n = 261) or strict rate control (n = 256). Results Baseline echocardiographic parameters were comparable between patients randomized to lenient and strict rate control. Between baseline and follow-up, significant adverse atrial or ventricular remodeling was not observed in either group. There were also no significant differences in atrial and ventricular remodeling between patients who continuously had heart rates between 80 and 110 beats/min and patients who continuously had heart rates ",

keywords = "atrial fibrillation, echocardiography, rate control, remodeling",

author = "Smit, {Marcelle D.} and Crijns, {Harry J. G. M.} and Tijssen, {Jan G. P.} and Hillege, {Hans L.} and Marco Alings and Tuininga, {Ype S.} and Groenveld, {Hessel F.} and {Van den Berg}, {Maarten P.} and {van Veldhuisen}, {Dirk J.} and {Van Gelder}, {Isabelle C.}",

year = "2011",

month = aug,

day = "23",

doi = "10.1016/j.jacc.2011.04.030",

language = "English",

volume = "58",

pages = "942--949",

journal = "Journal of the American College of Cardiology",

issn = "0735-1097",

publisher = "Elsevier Inc.",

number = "9",

}

Smit, MD, Crijns, HJGM, Tijssen, JGP, Hillege, HL, Alings, M, Tuininga, YS, Groenveld, HF, Van den Berg, MP, van Veldhuisen, DJ & Van Gelder, IC 2011, 'Effect of Lenient Versus Strict Rate Control on Cardiac Remodeling in Patients With Atrial Fibrillation', Journal of the American College of Cardiology, vol. 58, no. 9, pp. 942-949. https://doi.org/10.1016/j.jacc.2011.04.030

TY - JOUR

T1 - Effect of Lenient Versus Strict Rate Control on Cardiac Remodeling in Patients With Atrial Fibrillation

AU - Smit, Marcelle D.

AU - Crijns, Harry J. G. M.

AU - Tijssen, Jan G. P.

AU - Hillege, Hans L.

AU - Alings, Marco

AU - Tuininga, Ype S.

AU - Groenveld, Hessel F.

AU - Van den Berg, Maarten P.

AU - van Veldhuisen, Dirk J.

AU - Van Gelder, Isabelle C.

PY - 2011/8/23

Y1 - 2011/8/23

N2 - Objectives The aim of this study was to evaluate echocardiographic remodeling in permanent atrial fibrillation (AF) patients treated with either lenient or strict rate control. Background It is unknown whether in permanent AF, lenient rate control is associated with more adverse cardiac remodeling than strict rate control. Methods Echocardiography was conducted at baseline and at follow-up in 517 patients included in the RACE II (RAte Control Efficacy in permanent atrial fibrillation II) trial. Echocardiographic parameters were compared between patients randomized to lenient rate control (n = 261) or strict rate control (n = 256). Results Baseline echocardiographic parameters were comparable between patients randomized to lenient and strict rate control. Between baseline and follow-up, significant adverse atrial or ventricular remodeling was not observed in either group. There were also no significant differences in atrial and ventricular remodeling between patients who continuously had heart rates between 80 and 110 beats/min and patients who continuously had heart rates

AB - Objectives The aim of this study was to evaluate echocardiographic remodeling in permanent atrial fibrillation (AF) patients treated with either lenient or strict rate control. Background It is unknown whether in permanent AF, lenient rate control is associated with more adverse cardiac remodeling than strict rate control. Methods Echocardiography was conducted at baseline and at follow-up in 517 patients included in the RACE II (RAte Control Efficacy in permanent atrial fibrillation II) trial. Echocardiographic parameters were compared between patients randomized to lenient rate control (n = 261) or strict rate control (n = 256). Results Baseline echocardiographic parameters were comparable between patients randomized to lenient and strict rate control. Between baseline and follow-up, significant adverse atrial or ventricular remodeling was not observed in either group. There were also no significant differences in atrial and ventricular remodeling between patients who continuously had heart rates between 80 and 110 beats/min and patients who continuously had heart rates

KW - atrial fibrillation

KW - echocardiography

KW - rate control

KW - remodeling

U2 - 10.1016/j.jacc.2011.04.030

DO - 10.1016/j.jacc.2011.04.030

M3 - Article

C2 - 21851883

SN - 0735-1097

VL - 58

SP - 942

EP - 949

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 9

ER -

Effect of Lenient Versus Strict Rate Control on Cardiac Remodeling in Patients With Atrial Fibrillation

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Keywords

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