Effect of Itraconazole and Rifampin on the Pharmacokinetics of Olaparib in Patients With Advanced Solid Tumors: Results of Two Phase I Open-label Studies

Luc Dirix*, Helen Swaisland, Henk M. W. Verheul, Sylvie Rottey, Karin Leunen, Guy Jerusalem, Christian Rolfo, Dorte Nielsen, L. Rhoda Molife, Rebecca Kristeleit, Judith de Vos-Geelen, Morten Mau-Sorensen, Patricia Soetekouw, Carla van Herpen, Anitra Fielding, Karen So, Wendy Bannister, Ruth Plummer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)2286-2299
Number of pages14
JournalClinical Therapeutics
Volume38
Issue number10
DOIs
Publication statusPublished - Oct 2016

Keywords

  • CYP3A4
  • itraconazole
  • olaparib
  • pharmacokinetic
  • rifampin

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