TY - JOUR
T1 - Effect of increased protein intake on renal acid load and renal hemodynamic responses
AU - Teunissen-Beekman, Karianna F. M.
AU - Dopheide, Janneke
AU - Geleijnse, Johanna M.
AU - Bakker, Stephan J. L.
AU - Brink, Elizabeth J.
AU - de Leeuw, Peter W.
AU - van Baak, Marleen A.
PY - 2016/3
Y1 - 2016/3
N2 - Increased protein intake versus maltodextrin intake for 4 weeks lowers blood pressure. Concerns exist that high-protein diets reduce renal function. Effects of acute and 4-week protein intake versus maltodextrin intake on renal acid load, glomerular filtration rate and related parameters were compared in this study. Seventy-nine overweight individuals with untreated elevated blood pressure and normal kidney function were randomized to consume a mix of protein isolates (60 g/day) or maltodextrin (60 g/day) for 4 weeks in energy balance. Twenty-four-hour urinary potential renal acid load (uPRAL) was compared between groups. A subgroup (maltodextrin N = 27, protein mix N = 25) participated in extra test days investigating fasting levels and postprandial effects of meals supplemented with a moderate protein-or maltodextrin-load on glomerular filtration rate, effective renal plasma flow, plasma renin, aldosterone, pH, and bicarbonate. uPRAL was significantly higher in the protein group after 4 weeks (P
AB - Increased protein intake versus maltodextrin intake for 4 weeks lowers blood pressure. Concerns exist that high-protein diets reduce renal function. Effects of acute and 4-week protein intake versus maltodextrin intake on renal acid load, glomerular filtration rate and related parameters were compared in this study. Seventy-nine overweight individuals with untreated elevated blood pressure and normal kidney function were randomized to consume a mix of protein isolates (60 g/day) or maltodextrin (60 g/day) for 4 weeks in energy balance. Twenty-four-hour urinary potential renal acid load (uPRAL) was compared between groups. A subgroup (maltodextrin N = 27, protein mix N = 25) participated in extra test days investigating fasting levels and postprandial effects of meals supplemented with a moderate protein-or maltodextrin-load on glomerular filtration rate, effective renal plasma flow, plasma renin, aldosterone, pH, and bicarbonate. uPRAL was significantly higher in the protein group after 4 weeks (P
KW - Acid load
KW - carbohydrate
KW - glomerular filtration rate
KW - kidney
KW - protein
U2 - 10.14814/phy2.12687
DO - 10.14814/phy2.12687
M3 - Article
C2 - 26997623
SN - 2051-817X
VL - 4
JO - Physiological Reports
JF - Physiological Reports
IS - 5
M1 - e12687
ER -