TY - JOUR
T1 - Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data
AU - Campbell, Bruce C. V.
AU - van Zwam, Wim H.
AU - Goyal, Mayank
AU - Menon, Bijoy K.
AU - Dippel, Diederik W. J.
AU - Demchuk, Andrew M.
AU - Bracard, Serge
AU - White, Philip
AU - Davalos, Antoni
AU - Majoie, Charles B. L. M.
AU - van der Lugt, Aad
AU - Ford, Gary A.
AU - de la Ossa, Natalia
AU - Kelly, Michael
AU - Bourcier, Romain
AU - Donnan, Geoffrey A.
AU - Roos, Yvo B. W. E. M.
AU - Bang, Oh Young
AU - Nogueira, Raul G.
AU - Devlin, Thomas G.
AU - van den Berg, Lucie A.
AU - Clarencon, Frederic
AU - Burns, Paul
AU - Carpenter, Jeffrey
AU - Berkhemer, Olvert A.
AU - Yavagal, Dileep R.
AU - Pereira, Vitor Mendes
AU - Ducrocq, Xavier
AU - Dixit, Anand
AU - Quesada, Helena
AU - Epstein, Jonathan
AU - Davis, Stephen M.
AU - Jansen, Olav
AU - Rubiera, Marta
AU - Urra, Xabier
AU - Micard, Emilien
AU - Lingsma, Hester F.
AU - Naggara, Olivier
AU - Brown, Scott
AU - Guillemin, Francis
AU - Muir, Keith W.
AU - van Oostenbrugge, Robert J.
AU - Saver, Jeffrey L.
AU - Jovin, Tudor G.
AU - Hill, Michael D.
AU - Mitchell, Peter J.
AU - HERMES Collaboration
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background General anaesthesia (GA) during endovascular thrombectomy has been associated with worse patient outcomes in observational studies compared with patients treated without GA. We assessed functional outcome in ischaemic stroke patients with large vessel anterior circulation occlusion undergoing endovascular thrombectomy under GA, versus thrombectomy not under GA (with or without sedation) versus standard care (ie, no thrombectomy), stratified by the use of GA versus standard care. Methods For this meta-analysis, patient-level data were pooled from all patients included in randomised trials in PuMed published between Jan 1, 2010, and May 31, 2017, that compared endovascular thrombectomy predominantly done with stent retrievers with standard care in anterior circulation ischaemic stroke patients (HERMES Collaboration). The primary outcome was functional outcome assessed by ordinal analysis of the modified Rankin scale (mRS) at 90 days in the GA and non-GA subgroups of patients treated with endovascular therapy versus those patients treated with standard care, adjusted for baseline prognostic variables. To account for between-trial variance we used mixed-effects modelling with a random effect for trials incorporated in all models. Bias was assessed using the Cochrane method. The meta-analysis was prospectively designed, but not registered. Findings Seven trials were identified by our search; of 1764 patients included in these trials, 871 were allocated to endovascular thrombectomy and 893 were assigned standard care. After exclusion of 74 patients (72 did not undergo the procedure and two had missing data on anaesthetic strategy), 236 (30%) of 797 patients who had endovascular procedures were treated under GA. At baseline, patients receiving GA were younger and had a shorter delay between stroke onset and randomisation but they had similar pre-treatment clinical severity compared with patients who did not have GA. Endovascular thrombectomy improved functional outcome at 3 months both in patients who had GA (adjusted common odds ratio (cOR) 1.52, 95% CI 1.09-2.11, p=0.014) and in those who did not have GA (adjusted cOR 2.33, 95% CI 1.75-3.10, p<0.0001) versus standard care. However, outcomes were significantly better for patients who did not receive GA versus those who received GA (covariate-adjusted cOR 1.53, 95% CI 1.14-2.04, p=0.0044). The risk of bias and variability between studies was assessed to be low. Interpretation Worse outcomes after endovascular thrombectomy were associated with GA, after adjustment for baseline prognostic variables. These data support avoidance of GA whenever possible. The procedure did, however, remain effective versus standard care in patients treated under GA, indicating that treatment should not be withheld in those who require anaesthesia for medical reasons.
AB - Background General anaesthesia (GA) during endovascular thrombectomy has been associated with worse patient outcomes in observational studies compared with patients treated without GA. We assessed functional outcome in ischaemic stroke patients with large vessel anterior circulation occlusion undergoing endovascular thrombectomy under GA, versus thrombectomy not under GA (with or without sedation) versus standard care (ie, no thrombectomy), stratified by the use of GA versus standard care. Methods For this meta-analysis, patient-level data were pooled from all patients included in randomised trials in PuMed published between Jan 1, 2010, and May 31, 2017, that compared endovascular thrombectomy predominantly done with stent retrievers with standard care in anterior circulation ischaemic stroke patients (HERMES Collaboration). The primary outcome was functional outcome assessed by ordinal analysis of the modified Rankin scale (mRS) at 90 days in the GA and non-GA subgroups of patients treated with endovascular therapy versus those patients treated with standard care, adjusted for baseline prognostic variables. To account for between-trial variance we used mixed-effects modelling with a random effect for trials incorporated in all models. Bias was assessed using the Cochrane method. The meta-analysis was prospectively designed, but not registered. Findings Seven trials were identified by our search; of 1764 patients included in these trials, 871 were allocated to endovascular thrombectomy and 893 were assigned standard care. After exclusion of 74 patients (72 did not undergo the procedure and two had missing data on anaesthetic strategy), 236 (30%) of 797 patients who had endovascular procedures were treated under GA. At baseline, patients receiving GA were younger and had a shorter delay between stroke onset and randomisation but they had similar pre-treatment clinical severity compared with patients who did not have GA. Endovascular thrombectomy improved functional outcome at 3 months both in patients who had GA (adjusted common odds ratio (cOR) 1.52, 95% CI 1.09-2.11, p=0.014) and in those who did not have GA (adjusted cOR 2.33, 95% CI 1.75-3.10, p<0.0001) versus standard care. However, outcomes were significantly better for patients who did not receive GA versus those who received GA (covariate-adjusted cOR 1.53, 95% CI 1.14-2.04, p=0.0044). The risk of bias and variability between studies was assessed to be low. Interpretation Worse outcomes after endovascular thrombectomy were associated with GA, after adjustment for baseline prognostic variables. These data support avoidance of GA whenever possible. The procedure did, however, remain effective versus standard care in patients treated under GA, indicating that treatment should not be withheld in those who require anaesthesia for medical reasons.
KW - CONTROLLED-TRIAL
KW - THERAPY
KW - MR
U2 - 10.1016/S1474-4422(17)30407-6
DO - 10.1016/S1474-4422(17)30407-6
M3 - Article
SN - 1474-4422
VL - 17
SP - 47
EP - 53
JO - Lancet Neurology
JF - Lancet Neurology
IS - 1
ER -