Abstract
Angiopoietin-like protein 4 (ANGPTL4) plays a role in lipid partitioning by inhibiting lipoprotein lipase (LPL)-dependent plasma clearance of triacylglycerol in adipose tissue. We investigated the effects of diet-induced weight loss on plasma ANGPTL4 concentrations in relation to invivo adipose tissue LPL activity and lipolysis and adipose tissue ANGPTL4 release in overweight/obese participants. Sixteen individuals (BMI: 28-35kg/m(2); 10 women) were randomized to a dietary intervention composed of either a low-calorie diet (1250 kcal/day) for 12 weeks (n=9) or a very low-calorie diet (500 kcal/day) for 5 weeks, followed by a 4-week weight stable period. Before and after the intervention, we measured arteriovenous concentration differences in combination with adipose tissue blood flow before and after intake of a high-fat mixed meal with [U-C-13]-palmitate to assess invivo adipose tissue LPL activity and lipolysis. The intervention significantly reduced body weight (-8.6 +/- 0.6 kg, P
Original language | English |
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Article number | e13735 |
Number of pages | 10 |
Journal | Physiological Reports |
Volume | 6 |
Issue number | 13 |
DOIs | |
Publication status | Published - Jul 2018 |
Keywords
- Adipose tissue
- angiopoietin-like protein 4
- lipid metabolism
- lipoprotein lipase
- weight loss
- FREE FATTY-ACIDS
- LIPOPROTEIN-LIPASE
- TRIGLYCERIDE-METABOLISM
- ANGPTL4
- ADIPOCYTES
- EXERCISE
- MUSCLE
- INACTIVATION
- LIPOLYSIS
- GLUCOSE