Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies

Chiara Fabbri, Katherine E. Tansey, Roy H. Perlis, Joanna Hauser, Neven Henigsberg, Wolfgang Maier, Ole Mors, Anna Placentino, Marcella Rietschel, Daniel Souery, Gerome Breen, Charles Curtis, Sang-Hyuk Lee, Stephen Newhouse, Hamel Patel, Michael O'Donovan, Glyn Lewis, Gregory Jenkins, Richard M. Weinshilboum, Anne FarmerKatherine J. Aitchison, Ian Craig, Peter McGuffin, Koen Schruers, Joanna M. Biernacka, Rudolf Uher, Cathryn M. Lewis

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)945-954
Number of pages10
JournalEuropean Neuropsychopharmacology
Volume28
Issue number8
DOIs
Publication statusPublished - 1 Aug 2018

Keywords

  • CYP2C19
  • Gene
  • Antidepressant
  • Response
  • Side effects
  • Major depression
  • MAJOR DEPRESSIVE DISORDER
  • SEROTONIN REUPTAKE INHIBITORS
  • STAR-ASTERISK-D
  • CONTROLLED-TRIAL
  • DOUBLE-BLIND
  • ENZYMES
  • PHARMACOGENETICS
  • INVENTORY
  • GENOTYPES
  • EFFICACY

Cite this

Fabbri, C., Tansey, K. E., Perlis, R. H., Hauser, J., Henigsberg, N., Maier, W., Mors, O., Placentino, A., Rietschel, M., Souery, D., Breen, G., Curtis, C., Lee, S-H., Newhouse, S., Patel, H., O'Donovan, M., Lewis, G., Jenkins, G., Weinshilboum, R. M., ... Lewis, C. M. (2018). Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies. European Neuropsychopharmacology, 28(8), 945-954. https://doi.org/10.1016/j.euroneuro.2018.05.009