Effect of continuous intrathecal baclofen therapy in children: a systematic review

Annemieke I. Buizer*, Brian H. M. Martens, Casey Grandbois van Ravenhorst, Linda J. Schoonmade, Jules G. Becher, R. Jeroen Vermeulen

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review


Aim To investigate the effects of continuous intrathecal baclofen (ITB) therapy in children with cerebral palsy (CP) and other neurological conditions. Method This systematic review was conducted using standardized methodology, searching four electronic databases (PubMed, Embase, CINAHL, Cochrane Library) for relevant literature published between inception and September 2017. Included studies involved continuous ITB as an intervention and outcome measures relating to all International Classification of Functioning, Disability and Health: Children and Youth (ICF-CY) components. Results Thirty-three studies were identified, of which one, including 17 children with spastic CP, produced level II evidence, and the others, mainly non-controlled cohort studies, level IV and V. Outcomes at body function level were most frequently reported. Results suggest continuous ITB may be effective in reducing spasticity and dystonia in CP, as well as other neurological conditions, and may improve the ease of care and quality of life of children with CP, but the level of evidence is low. Interpretation Despite three decades of applying ITB in children and a relatively large number of studies investigating the treatment effects, a direct link has not yet been demonstrated because of the low scientific quality of the primary studies. Further investigation into the effects of continuous ITB at all levels of the ICF-CY is warranted. Although large, controlled trials may be difficult to realize, national and international collaborations may provide opportunities. Also, multicentre prospective cohort studies with a long-term follow-up, employing harmonized outcome measures, can offer prospects to expand our knowledge of the effects of continuous ITB therapy in children. What this paper adds

There is low-level evidence for continuous intrathecal baclofen (ITB) in children with cerebral palsy. Continuous ITB is effective in reducing spasticity and dystonia in non-controlled cohort studies. Evaluation of individual goals and systematic assessment of long-term effects in large cohort studies are required.

Original languageEnglish
Pages (from-to)128-134
Number of pages8
JournalDevelopmental Medicine and Child Neurology
Issue number2
Publication statusPublished - Feb 2019


  • LIFE
  • Hypertonia
  • Efficacy
  • Outcomes
  • Infusion
  • Non-ambulant children
  • Life
  • Dystonia
  • Safety
  • Spastic cerebral-palsy
  • Young-adults


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