Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease

M. Hadithi, C.J. Mulder, F. Stam, J. Azizi, J.B. Crusius, A.S. Pena, C.D. Stehouwer, Y.M. Smulders

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    Abstract

    AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003), folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management.
    Original languageEnglish
    Pages (from-to)955-960
    JournalWorld Journal of Gastroenterology
    Volume15
    Issue number8
    DOIs
    Publication statusPublished - 1 Jan 2009

    Cite this

    Hadithi, M., Mulder, C. J., Stam, F., Azizi, J., Crusius, J. B., Pena, A. S., Stehouwer, C. D., & Smulders, Y. M. (2009). Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease. World Journal of Gastroenterology, 15(8), 955-960. https://doi.org/10.3748/wjg.15.955